Vascular and Neurologic Exploration of Small Nervous Fiber by Sudoscanner and QST

Overview

Erythromelalgy (EM) is a vascular syndrome very rare affecting the feet. This disease evolve by crisis when the feet extremities become red hot and painful. There are several types of EM but this study concern the adult primitive form. For a long time, the physiopathology was not described but now we know that there is a vascular form, with microcirculatory dysfunction and a neurologic form with small fibers neuropathy. The diagnostic of neurologic form is based on clinical evaluation (DN4 questionnaire, UENS scale…) and an electromyography. Thermotest, a medical device which measure the thermic sensitivity is used to quantify neuropathy. More recently Sudoscan, a device measuring cutaneous impedance to chloride ions detect small nervous fiber in diabetic patients with good correlation with Thermotest. The purpose of this study is to analyze the vascular side and the neurologic side on patients consulting for Erythromelalgy.

Full Title of Study: “Vascular and Neurologic Exploration of Small Nervous Fiber by Sudoscanner”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: N/A
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Other
    • Masking: None (Open Label)
  • Study Primary Completion Date: January 18, 2018

Interventions

  • Other: impedance measurement and pain evaluation
    • Measurement of chlorine ions impedance by SUDOSCAN and pain due to temperature evaluation with THERMOTEST

Arms, Groups and Cohorts

  • Experimental: erythermalgia patient
    • patient will be measured chlorine ions impedance with the SUDOSCAN and evaluation on pain du to temperature with the THERMOTEST

Clinical Trial Outcome Measures

Primary Measures

  • Assessment of Chlorine ion production change
    • Time Frame: Day1
    • patient will be measured the impedance of chlorinates ions by Sudoscan
  • Assessment of Temperature changing sensitivity
    • Time Frame: Day1
    • Patients will be measured their sensitivity to temperature changing using the Thermotest

Participating in This Clinical Trial

Inclusion Criteria

  • Pain with burn feeling at hands and feet extremities – Crisis activated by the heat – Age > 18 years old Exclusion Criteria:

  • Patients who had burn in extremities

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Fondation Hôpital Saint-Joseph
  • Provider of Information About this Clinical Study
    • Sponsor

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