High Quality Evidence of Chinese Lupus Nephritis (HELP)

Overview

The investigators are registering LN patients at recruited hospitals and developing a LN database in China. Patients will be follow-up every year, and both baseline and follow-up information will be entered into the registration system.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: December 2026

Detailed Description

The investigators are registering Lupus nephritis (LN) and developing a LN database in China. Patients' demographic characteristics (including age, gender, height, weight, BMI, smoking, drinking, and education etc.), clinical characteristics (including systolic blood pressure, diastolic blood pressure, and lab measurements of whole blood, serum, urine etc.), complications, drug information at the baseline will be collected. Patients will be follow-up every year, the demographic and clinical characteristics, complications; drug information of patients will be collected at each visit. We will also record the outcome at each visit, such as mortality (including all-cause mortality and cardiovascular disease mortality), end-stage renal disease (ESRD) or serum creatinine doubling. The patient survival and renal survival will be compared using the LN database.

Interventions

  • Other: No Intervention
    • Registration of all LN patients in the First Affiliated Hospital of Sun Yat-sen University and other hospitals which have signed the contract in China.

Arms, Groups and Cohorts

  • LN patients
    • Patients diagnosis as lupus nephritis

Clinical Trial Outcome Measures

Primary Measures

  • All-cause mortality and cardiovascular mortality of LN patients
    • Time Frame: 10years
  • A composite renal outcome of LN patients
    • Time Frame: 10years
    • The composite renal outcome defined as doubling of serum creatinine and ESRD (defined as initiation of dialysis or kidney transplantation).

Participating in This Clinical Trial

Inclusion Criteria

  • Patients who diagnosis as lupus nephritis Exclusion Criteria:

  • No

Gender Eligibility: All

Minimum Age: 14 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Sun Yat-sen University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Xue Qing Yu, Professor – Sun Yat-sen University
  • Overall Contact(s)
    • Xueqing Yu, M.D. & Ph.D, yuxq@mail.sysu.edu.cn

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