Effects of a Pre-Workout Dietary Supplement on Training Adaptations

Overview

The purpose of this study is to examine the effects of a pre-workout dietary supplement during resistance training on training adaptations.

Full Title of Study: “Effects of a Pre-Workout Dietary Supplement on Training Adaptations in Resistance Trained Athletes”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Health Services Research
    • Masking: Double (Participant, Investigator)
  • Study Primary Completion Date: December 2014

Detailed Description

A number of nutritional strategies have been developed to optimize nutrient delivery prior to exercise. This includes providing carbohydrate and a number of ergogenic nutrients prior to, during and/or following exercise. As a result, a number of pre-workout supplements have been developed to increase energy availability, promote vasodilation and/or positively affect exercise capacity. The purpose of this study is to investigate the effects of ingesting a pre-workout dietary supplement during resistance training on training adaptations.

Interventions

  • Dietary Supplement: C4 Extreme, C4 Extreme (without Advantra Z)

Arms, Groups and Cohorts

  • Experimental: C4 Extreme
    • One dose of 12 grams (powder mixed with water): 1500 mg beta alanine, 1000 mg creatine nitrate, 1000 mg arginine alpha-ketoglutarate, 250 mg vitamin C, 150 mg N-Acetyl-Tyrosine, 135 mg caffeine, 7.5 mg L-Dopa, 30 mg vitamin B3, 10 mg Bitter Orange (Citrus Aurantium) fruit standardized for 30% synephrine (Advantra Z), 0.5 mg vitamin B6, 0.25 mg vitamin B9, and 0.035 mg vitamin B12.
  • Active Comparator: C4 Extreme (without Advantra Z)
    • One dose of 12 grams (powder mixed with water): 1500 mg beta alanine, 1000 mg creatine nitrate, 1000 mg arginine alpha-ketoglutarate, 250 mg vitamin C, 150 mg N-Acetyl-Tyrosine, 135 mg caffeine, 7.5 mg L-Dopa, 30 mg vitamin B3, 0.5 mg vitamin B6, 0.25 mg vitamin B9, and 0.035 mg vitamin B12.
  • Placebo Comparator: Placebo
    • One dose of flavored placebo (powder mixed with water)

Clinical Trial Outcome Measures

Primary Measures

  • Examine the effects of C4 supplementation during resistance training by assessing body water
    • Time Frame: Eight weeks
  • Examine the effects of C4 supplementation during resistance training by assessing body composition
    • Time Frame: Eight weeks
  • Examine the effects of C4 supplementation during resistance training by assessing macronutrient intake
    • Time Frame: Eight weeks
  • Examine the effects of C4 supplementation during resistance training by assessing 1 RM (repetition maximum) strength
    • Time Frame: Eight weeks
  • Examine the effects of C4 supplementation during resistance training by assessing anaerobic sprint capacity
    • Time Frame: Eight weeks
  • Examine the effects of C4 supplementation during resistance training by assessing muscle creatine levels
    • Time Frame: Eight weeks
  • Examine the effects of C4 supplementation during resistance training by assessing muscle carnosine levels
    • Time Frame: Eight weeks
  • Examine the effects of C4 supplementation during resistance training by assessing cognitive function (i.e., Stroop Color and Word Test, Word Recall Test and Readiness to perform VAS)
    • Time Frame: Eight weeks

Secondary Measures

  • Measure standard clinical chemistry panels in the blood to evaluate safety
    • Time Frame: Eight weeks
  • Record side effects to evaluate safety
    • Time Frame: Eight weeks
  • Measure heart rate to evaluate safety
    • Time Frame: Eight weeks
  • Measure blood pressure to evaluate safety
    • Time Frame: Eight weeks

Participating in This Clinical Trial

Inclusion Criteria

  • you are an apparently healthy and recreationally active male between the ages of 18 and 40. – you will need to have at least six months immediate prior history of resistance training on the bench press and leg press or squat. Exclusion Criteria:

  • you have a history of treatment for metabolic disease (i.e., diabetes), hypertension, hypotension, thyroid disease, arrhythmia and/or cardiovascular disease; – you are currently using prescription medications; – you have an intolerance to caffeine and/or other natural stimulants; – you have a history of smoking; – you drink excessively (i.e., 12 drinks per week or more);

Gender Eligibility: Male

Minimum Age: 18 Years

Maximum Age: 40 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Texas A&M University
  • Collaborator
    • Nutrabolt
  • Provider of Information About this Clinical Study
    • Sponsor

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At TrialBulletin.com, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.