The Effect of Oral Zinc Supplementation on Thiol Oxido-reductive Index

Overview

Although several studies have considered the relationship between infertility and semen thiol compounds levels, no study on the effects of asthenospermia treatments such as oral zinc supplementation on thiol related enzymes activity which are important in fertility of the individual has been reported.

Full Title of Study: “The Effect of Oral Zinc Supplementation on Thiol Oxido-reductive Index and Thiol Related Enzymes in Spermatozoa of Iraqi Asthenospermic Patients”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Non-Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Treatment
    • Masking: None (Open Label)
  • Study Primary Completion Date: July 2012

Detailed Description

The present study was conducted to study the effect of zinc supplementation on the quantitative and qualitative characteristics of semen along with reduced thiol, oxidized thiol and thiol related enzymes in the seminal plasma of asthenospermic patients.

Interventions

  • Dietary Supplement: zinc sulfate
    • The subfertile group treated with zinc sulfate, every participant took two capsules of zinc sulfate per day for three months (each one 220 mg).

Arms, Groups and Cohorts

  • Experimental: Zinc sulfate
    • 60 subfertile (age 32.5±3.23 year) men with asthenozoospermia was treated with zinc sulfate,every participant took two capsules of zinc sulfate per day for three months (each one 220 mg).
  • No Intervention: Healthy control
    • 60 fertile (age 31.6±3.3 year) men, no treatment

Clinical Trial Outcome Measures

Primary Measures

  • Thiol oxido-reductive index levels in spermatozoa and seminal plasma. The investigators evaluated the effects of zinc sulfate (220 mg/d) supplementation on Thiol oxido-reductive index levels.
    • Time Frame: up to three months.

Secondary Measures

  • Glutathione peroxidase activity levels in spermatozoa and seminal plasma. The investigators evaluated the effects of zinc sulfate (220 mg/d) supplementation on Glutathione peroxidase activity levels.
    • Time Frame: up to three months.
  • Sulfhydryl oxidase activity levels in spermatozoa and seminal plasma. The investigators evaluated the effects of zinc sulfate (220 mg/d) supplementation on Sulfhydryl oxidase activity levels.
    • Time Frame: up to three months.

Participating in This Clinical Trial

Inclusion Criteria

  • The presence of asthenozoospermia in the semen sample. Exclusion Criteria:

  • The absence of endocrinopathy, varicocele, and female factor infertility. Smokers and alcoholic men were excluded from the study because of their recognized high seminal ROS levels and decreased antioxidant levels.

Gender Eligibility: Male

Minimum Age: 26 Years

Maximum Age: 36 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • mahmoud hussein hadwan
  • Collaborator
    • Ministry of Health, Iraq
  • Provider of Information About this Clinical Study
    • Sponsor-Investigator: mahmoud hussein hadwan, Principal Investigator – Babylon University
  • Overall Official(s)
    • Mahmoud Hadwan, PhD, Principal Investigator, Babylon University
    • L Almashhedy, PhD, Study Director, Babylon University
    • Alsalman Abdulrrazaq, PhD, Study Chair, Babylon University

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