Pleth Variability Index and Hypotension


Correct assessment of a patient's volume status is the most important goal for an anesthetist. However, most of the variables used for fluid response evaluation are invasive and technically challenging.Pulse oximeter is a non-invasive, standardized and widely used monitoring method in many countries. Our aim in this study is to investigate the usefulness of the noninvasive pleth variability index to predict hypotension in orthopedic hip fracture patients who underwent spinal anesthesia.

Full Title of Study: “Hypotension Relationship With Pleth Variability Index In Hip Fracture Patients Who Underwent Spinal Anesthesia”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: October 2017


  • Device: pleth variability index

Clinical Trial Outcome Measures

Primary Measures

  • Detecting pleth variability index-hypotension relationship
    • Time Frame: one year

Secondary Measures

  • pleth variability index response to fluid management
    • Time Frame: one year
  • Make a differential diagnosis of hypotension with pleth variability index
    • Time Frame: one year
  • Correlation between arterial hemoglobin and pleth variability index hemoglobin
    • Time Frame: one year

Participating in This Clinical Trial

Inclusion Criteria

  • over 65 years old
  • Patients to undergo spinal anesthesia

Exclusion Criteria

  • Patients under 65 years old
  • Patients to undergo general anesthesia or only sedation
  • Patients with cardiac arrhythmia
  • Patients with low ventricular ejection fraction
  • Heart valve disease patients

Gender Eligibility: All

Minimum Age: 65 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Erzincan University
  • Provider of Information About this Clinical Study
    • Principal Investigator: ILKE KUPELI, assist. prof. – Erzincan University


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Forget P, Lois F, de Kock M. Goal-directed fluid management based on the pulse oximeter-derived pleth variability index reduces lactate levels and improves fluid management. Anesth Analg. 2010 Oct;111(4):910-4. doi: 10.1213/ANE.0b013e3181eb624f. Epub 2010 Aug 12.

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