Brown Adipose Tissue in Type 1 Diabetes
Overview
Brown adipose tissue has the capacity to consume large amounts of energy and has insulin-independent glucose uptake. The investigators have recently observed an inverse correlation between irisin levels and insulin needs of type 1 diabetes patients. Transplantation of brown adipose tissue to insulin-deficient rats normalized their blood glucose levels. In this study 12 patients with long-standing type 1 diabetes (>10 years) and with variable exogenous insulin needs will be investigated for amount of brown adipose tissue with positron emission tomography using the tracer 18F-deoxy glucose.
Full Title of Study: “Studies of Activity of Brown Adipose Tissue With Positron Emission Tomography Using the Tracer 18F-deoxy Glucose in Patients With Type 1 Diabetes”
Study Type
- Study Type: Interventional
- Study Design
- Allocation: N/A
- Intervention Model: Single Group Assignment
- Primary Purpose: Basic Science
- Masking: None (Open Label)
- Study Primary Completion Date: January 2018
Interventions
- Radiation: Positron emission tomography with tracer 18F-deoxy glucose
- Assessment of activity of brown adipose tissue with positron emission tomography using the tracer 18F-deoxy glucose
Arms, Groups and Cohorts
- Experimental: Type 1 diabetes
- Positron emission tomography with tracer 18F-deoxy glucose
Clinical Trial Outcome Measures
Primary Measures
- Activity of brown adipose tissue in correlation to exogenous insulin needs using the tracer 18F-deoxy glucose in positron emission tomography measurements
- Time Frame: Assessment performed after more than 10 years of diagnosed type 1 diabetes
Secondary Measures
- Glucose uptake in muscle in correlation to exogenous insulin needs; assessment using the tracer 18F deoxy glucose in positron emission tomography measurements.
- Time Frame: Assessment performed after more than 10 years of diagnosed type 1 diabetes
Participating in This Clinical Trial
Inclusion Criteria
1. Adult patients (18 years of age or more) 2. Type 1 diabetes diagnose for more than 10 years Exclusion Criteria:
1. Ongoing pregnancy 2. Ongoing breast-feeding 3. BMI<19 4. BMI >30 5. P-creatinine <110 µmol/l
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: N/A
Are Healthy Volunteers Accepted: No
Investigator Details
- Lead Sponsor
- Per-Ola Carlsson
- Provider of Information About this Clinical Study
- Sponsor-Investigator: Per-Ola Carlsson, Professor, Senior consultant – Uppsala University Hospital
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