Brown Adipose Tissue in Type 1 Diabetes

Overview

Brown adipose tissue has the capacity to consume large amounts of energy and has insulin-independent glucose uptake. The investigators have recently observed an inverse correlation between irisin levels and insulin needs of type 1 diabetes patients. Transplantation of brown adipose tissue to insulin-deficient rats normalized their blood glucose levels. In this study 12 patients with long-standing type 1 diabetes (>10 years) and with variable exogenous insulin needs will be investigated for amount of brown adipose tissue with positron emission tomography using the tracer 18F-deoxy glucose.

Full Title of Study: “Studies of Activity of Brown Adipose Tissue With Positron Emission Tomography Using the Tracer 18F-deoxy Glucose in Patients With Type 1 Diabetes”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: N/A
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Basic Science
    • Masking: None (Open Label)
  • Study Primary Completion Date: January 2018

Interventions

  • Radiation: Positron emission tomography with tracer 18F-deoxy glucose
    • Assessment of activity of brown adipose tissue with positron emission tomography using the tracer 18F-deoxy glucose

Arms, Groups and Cohorts

  • Experimental: Type 1 diabetes
    • Positron emission tomography with tracer 18F-deoxy glucose

Clinical Trial Outcome Measures

Primary Measures

  • Activity of brown adipose tissue in correlation to exogenous insulin needs using the tracer 18F-deoxy glucose in positron emission tomography measurements
    • Time Frame: Assessment performed after more than 10 years of diagnosed type 1 diabetes

Secondary Measures

  • Glucose uptake in muscle in correlation to exogenous insulin needs; assessment using the tracer 18F deoxy glucose in positron emission tomography measurements.
    • Time Frame: Assessment performed after more than 10 years of diagnosed type 1 diabetes

Participating in This Clinical Trial

Inclusion Criteria

1. Adult patients (18 years of age or more) 2. Type 1 diabetes diagnose for more than 10 years Exclusion Criteria:

1. Ongoing pregnancy 2. Ongoing breast-feeding 3. BMI<19 4. BMI >30 5. P-creatinine <110 µmol/l

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Per-Ola Carlsson
  • Provider of Information About this Clinical Study
    • Sponsor-Investigator: Per-Ola Carlsson, Professor, Senior consultant – Uppsala University Hospital

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