Pupillometry in Horner’s Syndrome

Overview

Horner's syndrome (HS) is a result of interruption of the sympathetic innervation to the eye and ocular adnexa, which can occur due to carotid artery dissection (CAD), along which the sympathetic nerve fibers travel to reach the eye. Dissection of the carotid artery is one of the etiologies for ischemic stroke in young patients.

In our current study, we will explore the diagnostic accuracy of automated binocular pupillometry in the diagnosis or HS, and its potential in identifying dissection of the carotid artery in patients of young age who suffer ischemic stroke.

Full Title of Study: “Automated Pupillometry for the Diagnosis of Horner’s Syndrome in Acute Stroke Patients Due to Carotid Artery Dissection”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: N/A
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Diagnostic
    • Masking: None (Open Label)
  • Study Primary Completion Date: February 2019

Interventions

  • Device: Automated pupillometry
    • Automated pupillometry will be performed in patients with acute stroke with the intention of diagnosing Horner’s syndrome

Arms, Groups and Cohorts

  • Experimental: Pupillometry in stroke patients
    • All eligible patients will undergo pupillometry test for the finding of Horner’s syndrome

Clinical Trial Outcome Measures

Primary Measures

  • Finding of pupillary dilation lag using pupillometry in patients with acute stroke due to carotid artery dissection
    • Time Frame: 1 day of initial visit

Participating in This Clinical Trial

Inclusion Criteria

  • Adults 60 years of age or younger
  • Acute stroke (less than 72 hours from admission)
  • Informed Consent as documented by signature (Appendix Informed Consent Form)
  • Ability to understand the study information and consent form

Exclusion Criteria

  • known history of HS
  • Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc.
  • Medications affecting pupillary response
  • History of ocular surgery affecting the pupil

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 60 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • University of Zurich
  • Provider of Information About this Clinical Study
    • Principal Investigator: Konrad Peter Weber, Principal Investigator – University of Zurich
  • Overall Official(s)
    • Konrad P Weber, MD, Principal Investigator, Ophthalmology Department, University Hospital Zurich

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