Metabolome Analysis in Patients With Rheumatoid Arthritis

Overview

The aim of this study is to investigate discriminant metabolites in urine from patients with rheumatoid arthritis (RA) from healthy individuals. Then we determine if the patient's metabolic fingerprint could predict the development or flare-up of RA.

Study Type

  • Study Type: Observational [Patient Registry]
  • Study Design
    • Time Perspective: Cross-Sectional
  • Study Primary Completion Date: October 2018

Detailed Description

Compare metabolites between RA patients and healthy individuals. 1. Collection urine sample 2. Assessing urine metabolites by 1H NMR spectroscopy 3. Analyzing the relationships between metabolites and clinical variables

Clinical Trial Outcome Measures

Primary Measures

  • Metabolic fingerprint of rheumatoid arthritis
    • Time Frame: 1 years
    • Metabolomic analyses of urine from patients with rheumatoid arthritis, healthy controls and other autoimmune disease

Secondary Measures

  • Correlations between specific metabolites and disease activity/severity of RA
    • Time Frame: 1 year
    • Identified metabolites and their clinical significances

Participating in This Clinical Trial

Inclusion Criteria

  • All patients with rheumatoid arthritis meet 2010 American College of Rheumatology/European League against Rheumatism classification criteria. Exclusion Criteria:

  • Comorbid with other autoimmune diseases – Confirmed with amyloidosis – Chronic kidney disease (estimated GFR < 60 ml/min/1.73m2) – Chronic liver disease – Thyroid disease – Pregnancy – Solid tumor/hematologic malignancy within 5 years

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • The Catholic University of Korea
  • Provider of Information About this Clinical Study
    • Principal Investigator: Jung Hee Koh, MD – The Catholic University of Korea
  • Overall Official(s)
    • Jung Hee Koh, MD, Principal Investigator, Seoul St.Mary’s hospital, The Catholic university of Korea

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