Parental Consanguinity and Family History of Kidney Disease in Turkish Kidney Disease Population

Overview

Inbreeding and consanguineous marriages are known to increase the risk of autosomal recessive disorders. The aim of this study was to examine the association between consanguinity and kidney diseases in the adult Turkish population.

Full Title of Study: “The Importance of Parental Consanguinity and Family History of Kidney Disease in Turkish Adult Chronic Kidney Disease Population”

Study Type

  • Study Type: Observational [Patient Registry]
  • Study Design
    • Time Perspective: Cross-Sectional
  • Study Primary Completion Date: May 2016

Detailed Description

This was a national, cross-sectional study recruiting patients from nephrology out-patient clinics and dialysis units. All patients between 18 and 70 years of age who were on follow up in outpatient clinic and dialysis unit at the Istanbul Medical Faculty from October 2009 to October 2015 were included in the study. All patients and healthy controls enrolled in this study gave informed consent to participate in the survey. They were all asked to answer a questionnaire including socio-demographic data, history of familial kidney disease and consanguineous marriage. Additional information was obtained from their private physicians and medical files. To ensure reliability of administration of the questionnaire, all interviewers underwent training using a standardized protocol.

Interventions

  • Other: Patients
    • In this study we aimed to investigate effect of family history and consanguineous marriage in the development of CKD in the adult Turkish population.

Arms, Groups and Cohorts

  • Patients
    • Patients who have chronic kidney diseases
  • Healthy controls
    • Healthy subjects

Clinical Trial Outcome Measures

Primary Measures

  • Effect of parental consanguinity on chronic kidney disease confirmed by a questionnaire did they have consanguinity marriage or not.
    • Time Frame: 6 months after enrollment

Secondary Measures

  • Effect of family history of kidney disease on the development of chronic kidney confirmed by a questionnaire did they have any parents with chronic kidney diseases or not.
    • Time Frame: 6 months after enrollment

Participating in This Clinical Trial

Inclusion Criteria

  • follow up in outpatient clinic and dialysis unit at the Istanbul Medical Faculty – between 18-70 years old – provide informed consent Exclusion Criteria:

  • follow-up shorter than 6 months – patients whose data were not available – patients who were unwilling or unable to provide informed consent

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 70 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Istanbul University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Yasar Caliskan, Principal Investigator – Istanbul University
  • Overall Official(s)
    • Yasar Caliskan, Dr., Principal Investigator, Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Nephrology

Citations Reporting on Results

National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002 Feb;39(2 Suppl 1):S1-266. No abstract available.

Chronic Kidney Disease Prognosis Consortium; Matsushita K, van der Velde M, Astor BC, Woodward M, Levey AS, de Jong PE, Coresh J, Gansevoort RT. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis. Lancet. 2010 Jun 12;375(9731):2073-81. doi: 10.1016/S0140-6736(10)60674-5. Epub 2010 May 17.

Suleymanlar G, Utas C, Arinsoy T, Ates K, Altun B, Altiparmak MR, Ecder T, Yilmaz ME, Camsari T, Basci A, Odabas AR, Serdengecti K. A population-based survey of Chronic REnal Disease In Turkey–the CREDIT study. Nephrol Dial Transplant. 2011 Jun;26(6):1862-71. doi: 10.1093/ndt/gfq656. Epub 2010 Nov 4.

Gumprecht J, Zychma MJ, Grzeszczak W, Zukowska-Szczechowska E; End-stage Renal Disease Study Group. Human SA gene Pst1 polymorphism and chronic renal failure: results of the family-based study. Nephrol Dial Transplant. 2001 Feb;16(2):387-90. doi: 10.1093/ndt/16.2.387.

O'Dea DF, Murphy SW, Hefferton D, Parfrey PS. Higher risk for renal failure in first-degree relatives of white patients with end-stage renal disease: a population-based study. Am J Kidney Dis. 1998 Nov;32(5):794-801. doi: 10.1016/s0272-6386(98)70135-0.

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