Action-effect Anticipation in Patients With Parkinson’s Disease : A Study of the Sensory Attenuation Marker.

Overview

The ideomotor theory of action control is considered to be central to the understanding of human voluntary action. According to the ideomotor theory, an action is represented in terms of its desired sensory effects and actions are selected by internally activating these effect representations. Recent imagery and behavioral studies showed that this anticipated representation of action-effects triggered a "sensory attenuation", meaning a decrease of perceptive performances or a decrease of sensory event-related potentials (ERP) for an expected event. Thus, the sensory attenuation constitutes a relevant behavioral tool to investigate sensory anticipation impairment in patients with Parkinson's disease. In a behavioral paradigm, patients and matched control participants have to perform a perceptive task on predicted visual action-effects mixed with mispredicted visual action effects. Performances should be better in mispredicted visual action effects for control participants only.

Full Title of Study: “The Process of Sensory Anticipation in Patients With PARKINSON’s Disease”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Cross-Sectional
  • Study Primary Completion Date: September 2018

Interventions

  • Behavioral: behavioral observation

Arms, Groups and Cohorts

  • Patients with Parkinson’s disease

Clinical Trial Outcome Measures

Primary Measures

  • median score
    • Time Frame: baseline
    • scores measured with the Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS)

Participating in This Clinical Trial

Inclusion Criteria

  • Parkinson's disease – Normal or corrected vision Exclusion Criteria:

  • Other pathology or neurological or psychiatric history – Known pregnancy or breastfeeding – Absence of affiliation to the French Social Security – Person under legal protection – Patient's opposition to participate

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Fondation Ophtalmologique Adolphe de Rothschild
  • Provider of Information About this Clinical Study
    • Sponsor

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