Dynamic ASPECTS of Internal PRE-ACTIVATION of Effects Sensors of Voluntary ACTION in PARKINSON’s Disease

Overview

The ability to predict sensory effects of people's own motor actions is a key component of Human action realization. Recent studies revealed this anticipation process to be involved in early and late stages of voluntary actions. Nevertheless, the question whether the action-effect anticipation is impacted or not by "motor pathologies", such as the Parkinson's disease, remains unclear. The current study is aimed to clarify this issue by using a subliminal priming paradigm in patients with Parkinson's disease and in matched control participants. Indeed, subliminal primes corresponding to visual action-effects are displayed at different time points before the actions' execution. Results should allow to determine whether or not the action-effect prediction is impaired at different stages of voluntary action in patients with Parkinson's disease.

Full Title of Study: “The Impact of Parkinson’s Disease on Internal Preactivation of Sensory Effects of Intention-based Actions. A Subliminal Priming Study”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Cross-Sectional
  • Study Primary Completion Date: June 2016

Interventions

  • Behavioral: Behavioral observation

Arms, Groups and Cohorts

  • Parkinson’s disease
  • Healthy subjects
    • gender and age matched with Parkinson’s disease patients, whose data will be extracted from an existing database

Clinical Trial Outcome Measures

Primary Measures

  • Reaction time
    • Time Frame: baseline
    • time measured in seconds
  • error rate
    • Time Frame: baseline

Participating in This Clinical Trial

Inclusion Criteria

  • Adults age 18 years and older – Parkinson's disease Exclusion Criteria:

  • Other pathology or neurological or psychiatric history – Known pregnancy or breastfeeding – Absence of affiliation to social security or universal health coverage (CMU) – Person under legal protection – Patient's opposition to participate

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Fondation Ophtalmologique Adolphe de Rothschild
  • Provider of Information About this Clinical Study
    • Sponsor

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