Role of Calcium Channels in Vascular Function


The purpose of this study is to examine the role of T-type calcium channels in endothelial dysfunction observed with ageing.

Full Title of Study: “Role of T-type Calcium Channels in Vascular Function”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Basic Science
    • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Study Primary Completion Date: May 25, 2021


  • Drug: Efonidipine
    • 8 weeks treatment with either efonidipine
  • Drug: Nifedipine
    • 8 weeks treatment with either nifedipine

Arms, Groups and Cohorts

  • Experimental: L + T-type
    • 8 weeks treatment with efonidipine (1 week 1x20mg, 7 weeks 2x20mg)
  • Active Comparator: L-Type
    • 8 weeks treatment with nifedipine (1 week 1x20mg, 7 weeks 2x20mg)

Clinical Trial Outcome Measures

Primary Measures

  • Vascular function
    • Time Frame: 8 weeks
    • Hemodynamic response to femoral arterially infused vasoactive substances

Participating in This Clinical Trial

Inclusion Criteria

  • age 20 – 30 and 60-70 – BMI < 30 Exclusion Criteria:

  • Hypertension (>150/90 mmHg) – Smoking – Physical activity >2 hours/week – Known chronic diseases – Pregnancy or birth within 3 month – Alcohol misuse

Gender Eligibility: All

Minimum Age: 20 Years

Maximum Age: 70 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • University of Southern Denmark
  • Provider of Information About this Clinical Study
    • Principal Investigator: Stefan Mortensen, Associate Professor – University of Southern Denmark

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