Role of Calcium Channels in Vascular Function

Overview

The purpose of this study is to examine the role of T-type calcium channels in endothelial dysfunction observed with ageing.

Full Title of Study: “Role of T-type Calcium Channels in Vascular Function”

Study Type

• Study Type: Interventional
• Study Design
  • Allocation: Randomized
  • Intervention Model: Parallel Assignment
  • Primary Purpose: Basic Science
  • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
• Study Primary Completion Date: May 25, 2021

Interventions

• Drug: Efonidipine
  • 8 weeks treatment with either efonidipine
• Drug: Nifedipine
  • 8 weeks treatment with either nifedipine

Arms, Groups and Cohorts

• Experimental: L + T-type
  • 8 weeks treatment with efonidipine (1 week 1x20mg, 7 weeks 2x20mg)
• Active Comparator: L-Type
  • 8 weeks treatment with nifedipine (1 week 1x20mg, 7 weeks 2x20mg)

Clinical Trial Outcome Measures

Primary Measures

• Vascular function
  • Time Frame: 8 weeks
  • Hemodynamic response to femoral arterially infused vasoactive substances

Participating in This Clinical Trial

Inclusion Criteria

• age 20 – 30 and 60-70 – BMI < 30 Exclusion Criteria:

• Hypertension (>150/90 mmHg) – Smoking – Physical activity >2 hours/week – Known chronic diseases – Pregnancy or birth within 3 month – Alcohol misuse

Gender Eligibility: All

Minimum Age: 20 Years

Maximum Age: 70 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

• Lead Sponsor
  • University of Southern Denmark
• Provider of Information About this Clinical Study
  • Principal Investigator: Stefan Mortensen, Associate Professor – University of Southern Denmark