The Three-dimensional Gait Analysis of Medial Knee Osteoarthritis

Overview

Static imaging has been commonly and clinically accepted to assess the severity of medial knee osteoarthritis (KOA), especially the radiography. Gait analysis has been adopted to evaluate the kinematic characteristics of the knees in patients with KOA. Most of the current studies focus on the sagittal plane of the knee, but very few of them focus on the frontal or horizontal plane. With the different severity of medial KOA, anatomical structures of the knees will change and influence kinematics of the knees, such as osteophytes and deformity. At present, there has been no study focusing on the relations between the imaging assessment of the severity and quantitative kinematics of medial KOA. The aim of the study is to explore the relationship between the imaging assessment based on the Kellgren-Lawrence Scores and in vivo 3D knee kinematic characteristics in Chinese patients with medial KOA during walking using a new portal gait system.

Full Title of Study: “The Relationship Between the Imaging Assessment Based on Kellgren-Lawrence Scores and In Vivo 3D Knee Kinematic Characteristics in Chinese Patients With Medial Knee Osteoarthritis During Walking Using a New Portal Gait System.”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: September 2016

Detailed Description

All patients are assessed according to the Kellgren-Lawrence Score.

Interventions

  • Other: Steps 1
    • Kinematic characteristics are obtained by the portal gait analysis system in the patients. Kellgren-Lawrence Scores are obtained according to their radiography.
  • Other: Steps 2
    • Kinematic characteristics are obtained by the portal gait analysis system in the subjects.Physical examinations are taken to avoid other diseases.

Arms, Groups and Cohorts

  • Early OA
    • All patients (>35 years) have been diagnosed with medial knee osteoarthritis according to the American College of Rheumatology criteria. Those are classified as patients with early knee osteoarthritis because their Kellgren-Lawrence Scores were Grade I.
  • Moderate OA
    • All patients (>35 years) have been diagnosed with medial knee osteoarthritis according to the American College of Rheumatology criteria. Those are classified as patients with moderate knee osteoarthritis because their Kellgren-Lawrence Scores were Grade II.
  • Severe OA
    • All patients (>35 years) have been diagnosed with medial knee osteoarthritis according to the American College of Rheumatology criteria. Those are classified as patients with moderate knee osteoarthritis because their Kellgren-Lawrence Scores were Grade III/IV.
  • Asymptomatic Participants
    • The asymptomatic participants(>35 years) has no history of knee pain, trauma, surgery, or obvious gait abnormalities. They are set as controls in the study.

Clinical Trial Outcome Measures

Primary Measures

  • Kinematic characteristics of the the six-degree-of-motion (6DOF) of the gait at heel strike in asymptomatic participants and patients with knee osteoarthritis.
    • Time Frame: 1 Day
    • The 6DOF include flexion/extension, internal/external rotation, varus/valgus, anterior/posterior translation, medial/lateral translation, proximal/distal translation.
  • Kinematic characteristics of the 6DOF of the gait at the mid-stance phase in asymptomatic participants and patients with knee osteoarthritis.
    • Time Frame: 1 Day
    • The 6DOF include flexion/extension, internal/external rotation, varus/valgus, anterior/posterior translation, medial/lateral translation, proximal/distal translation.
  • Kinematic characteristics of the 6DOF of the gait at the maximum motion in swing phase in asymptomatic participants and patients with knee osteoarthritis.
    • Time Frame: 1 Day
    • The 6DOF include flexion/extension, internal/external rotation, varus/valgus, anterior/posterior translation, medial/lateral translation, proximal/distal translation.

Secondary Measures

  • Kellgren-Lawrence Scores in patients with knee osteoarthritis.
    • Time Frame: 1 Day

Participating in This Clinical Trial

Inclusion Criteria

1. Clinical diagnosis of medial knee osteoarthritis according to the American College of Rheumatology criteria. 2. The patients are confirmed by radiographic evidence that medial tibiofemoral joint space grade was narrower than lateral tibiofemoral joint space. 3. The patients have clinical symptom of medial pain of the knee. 4. Clinical examinations are taken to examine the asymptomatic subjects to avoid knee diseases. Exclusion Criteria:

1. Traumatic knee osteoarthritis. 2. Lateral tibiofemoral KOA or any other types of Knee OA. 3. Ambiguity of Kellgren-Lawrence scores 4. History of surgery. 5. Neuromuscular disease, cardiovascular disease or trauma that can affects gait. 6. Body mass index greater than 35. 7. Needing stick or assistance to walk or unable to walk at a speed of less than 2.0 km/h and less than 300 m.

Gender Eligibility: All

Minimum Age: 35 Years

Maximum Age: 80 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Guangzhou General Hospital of Guangzhou Military Command
  • Collaborator
    • Medical Center of Assessment, Prevention and Treatment of Bone & Joint Diseases, Guangdong, China
  • Provider of Information About this Clinical Study
    • Principal Investigator: Yu Zhang, chief surgeon, associate professor – Guangzhou General Hospital of Guangzhou Military Command
  • Overall Official(s)
    • Yu Zhang, PhD, Study Chair, Hospital of Orthopedics, Guangzhou General Hospital of Guangzhou Military Command, 111 Liuhua Road, Guangzhou 510010, China

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