Prognostic Factors Affecting Outcomes in Multivisceral en Bloc Resection for Colorectal Cancer

Overview

Determine clinical and pathological factors associated with perioperative morbidity and mortality, and oncological outcomes after multivisceral en bloc resection in patients with colorectal cancer.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: N/A
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Treatment
    • Masking: None (Open Label)
  • Study Primary Completion Date: February 2014

Detailed Description

Between January/2009 and February/2014, 105 patients with primary colorectal cancer selected for multivisceral resection were selected from a prospective database. Clinical and pathological factors, perioperative morbidity and mortality and outcome were verified from medical records. Estimated local recurrence, and overall survival were compared using the log rank method, and Cox regression analysis was used to determine the independence of the studied parameters.

Interventions

  • Procedure: Multivisceral en bloc resection surgery
    • Multivisceral en bloc resection for colorectal cancer in advance patients (T4)

Arms, Groups and Cohorts

  • Other: Multiviceral resection colorectal cancer
    • Multiviceral resection surgery of 2 or more intrabdominal organs en bloc with colorectal cancer

Clinical Trial Outcome Measures

Primary Measures

  • Survival
    • Time Frame: 3 years
    • diseases free survival

Secondary Measures

  • Recurrence
    • Time Frame: 3 years
    • months after local or systemic recurrence for colorectal cancer

Participating in This Clinical Trial

Inclusion Criteria

  • T4 Colorectal cancer - Exclusion Criteria:

  • Non primary Colorectal cancer -

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 70 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • University of Sao Paulo
  • Collaborator
    • CAIO SERGIO NAHAS
  • Provider of Information About this Clinical Study
    • Principal Investigator: Leonardo Alfonso Bustamante, M.D – University of Sao Paulo

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