Oral Carvedilol in Escalating Doses in the Acute Treatment of Atrial Fibrillation


Oral carvedilol administered in escalating doses in patients with atrial fibrillation among patients with AF with fast ventricular rate.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: N/A
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Treatment
    • Masking: None (Open Label)
  • Study Primary Completion Date: March 2002

Detailed Description

Patients with AF with FVR of any etiology were evaluated and given escalating doses of oral carvedilol in doses – 3.125mg OD, then 3.125 bid, then 6.25mg bid, then 12.5mg bid. The ECG was recorded regularly and analysed for rate reduction or control.


  • Drug: oral carvedilol
    • oral carvedilol in escalating doses for reducing ventricular rate in AF patients

Arms, Groups and Cohorts

  • Experimental: active arm
    • single arm study with one group given oral carvedilol.

Clinical Trial Outcome Measures

Primary Measures

  • reduction in ventricular rate in AF patients
    • Time Frame: 24 hours
    • reduction in ventricular rate in patients with AF and fast ventricular rate.

Participating in This Clinical Trial

Inclusion Criteria

  • AF with fast ventricular rate

Exclusion Criteria

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 80 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Andhra Medical College
  • Provider of Information About this Clinical Study
    • Principal Investigator: Ravi Venkatachelam Chitrapu, doctor – Andhra Medical College

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