MRI of Infrapatellar Fat Pad in Osteoarthritis

Overview

In this study, the investigators use the clinical documentation and imaging data of MRI to do research. Clinical subjects were divided into two groups: osteoarthritis patients and healthy controls without osteoarthritis. Differences of MRI data were studied between two groups.

Full Title of Study: “Magnetic Resonance Imaging of Infrapatellar Fat Pad in Osteoarthritis and Controls”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Cross-Sectional
  • Study Primary Completion Date: July 2016

Detailed Description

In this study, the investigators applied high precision MRI technique (with as less as a slice thickness of 0.35 mm and without inter-slice gap), and calculated not only the IPFP maximal sagittal area and IPFP volume, but also the quantitated signal, and compared the differences between healthy controls and osteoarthritis patients. This is an observational cross-sectional study without specific interventions to the subjects. MRI is a regular examination in our hospital. And all subjects are included for the reasons of osteoarthritis (need MRI) and healthy controls (pain but not osteoarthritis, also need MRI). The investigator does not assign specific interventions to the subjects of the study.

Interventions

  • Radiation: Magnetic resonance imaging
    • 3.0 T Magnetic resonance imaging of knee joints. It does not harm the subjects.

Arms, Groups and Cohorts

  • osteoarthritis patients
    • 3.0 Tesla Magnetic resonance imaging was analyzed. It’s the documentation from the outpatients and inpatients with osteoarthritis. It’s not the intervention the study applied, but the subjects’ disease demands.
  • healthy controls
    • 3.0 Tesla Magnetic resonance imaging was analyzed. It’s the documentation from the outpatients and inpatients without osteoarthritis. It’s not the intervention the study applied, but the subjects’ non-osteoarthritis knee symptom demands.

Clinical Trial Outcome Measures

Primary Measures

  • Infrapatellar Fat Pad Volume in MRI
    • Time Frame: collect the data within 24 hours after the subjects did the MRI

Participating in This Clinical Trial

Inclusion Criteria

  • Patients with clinical knee osteoarthritis; – The healthy controls who require MRI test. Exclusion Criteria:

  • Contraindications to magnetic resonance imaging; – Rheumatoid arthritis patients; – Gout; – Hemophilic arthritis; – Subjects who take non-steroidal anti-inflammatory drugs (NSAIDs); – Subjects who take lipid-lowering agents; – Subjects who have the history of knee trauma; – Subjects who have the history of knee operation; – Subjects who have the disease of musculoskeletal tumor near knee; – Subjects who have joint loose bodies.

Gender Eligibility: All

Minimum Age: N/A

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • The Third Xiangya Hospital of Central South University
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Jinshen He, MD, Principal Investigator, Department of Orthopaedic Surgery, Third Xiangya Hospital of Central South University

References

Pan F, Han W, Wang X, Liu Z, Jin X, Antony B, Cicuttini F, Jones G, Ding C. A longitudinal study of the association between infrapatellar fat pad maximal area and changes in knee symptoms and structure in older adults. Ann Rheum Dis. 2015 Oct;74(10):1818-24. doi: 10.1136/annrheumdis-2013-205108. Epub 2014 May 15.

Han W, Aitken D, Zhu Z, Halliday A, Wang X, Antony B, Cicuttini F, Jones G, Ding C. Signal intensity alteration in the infrapatellar fat pad at baseline for the prediction of knee symptoms and structure in older adults: a cohort study. Ann Rheum Dis. 2016 Oct;75(10):1783-8. doi: 10.1136/annrheumdis-2015-208360. Epub 2015 Nov 26.

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At TrialBulletin.com, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.