Evaluation of Novel Lung Function Parameters in Patients With Interstitial Lung Disease (ILD)

Overview

Current diagnostic tools used in interstitial lung disease (ILD) do not meet the challenges set by the complex pathophysiology of this heterogenous group. The investigators therefore aimed to evaluate novel or not widely used diagnostic approaches for the detection and therapeutic monitoring of patients with various ILDs.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: December 2020

Interventions

  • Device: multiple breath washout tests
  • Device: impulse oscillometry
  • Device: body plethysmography

Arms, Groups and Cohorts

  • interstitial lung disease
    • patients with known or suspected ILD such as idiopathic pulmonary fibrosis, non-specific interstitial pneumonia, sarcoidosis, granulomatosis with polyangiitis
  • pulmonary healthy controls
    • patients without known or suspected pulmonary disease

Clinical Trial Outcome Measures

Primary Measures

  • lung clearance index (LCI) as determined by multiple breath washout
    • Time Frame: 30 minutes
  • airway resistance and reactance (R5, X5, R-D5-20) as determined by impulse oscillometry
    • Time Frame: 30 minutes

Secondary Measures

  • repeatability of lung clearance index (LCI)
    • Time Frame: 30 minutes

Participating in This Clinical Trial

Inclusion Criteria

  • known or suspected interstitial lung disease Exclusion Criteria:

  • pregnancy – inability to participate

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Universitätsmedizin Mannheim
  • Provider of Information About this Clinical Study
    • Principal Investigator: Dr. Frederik Trinkmann, Principal Investigator – Universitätsmedizin Mannheim
  • Overall Contact(s)
    • Frederik Trinkmann, Dr., +496213833879, frederik.trinkmann@umm.de

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