Acute Pain Trajectories and Persistent Pain After Breast Cancer Surgery

Overview

Persistent pain after breast cancer surgery (PPBCS) is a significant clinical problem, affecting between 25 and 50% of patients. Several factors are associated with the development of PPBCS, including acute postoperative pain. The analysis of pain trajectories through mixed model modeling is an alternative to static pain measures, improving precision and providing information on the time course of pain resolution. Our aim was to investigate if the characteristics of pain trajectories during the first postoperative week are correlated with the persistence of pain 3 months after breast cancer surgery.

Full Title of Study: “Acute Pain Trajectories as a Predictive Factor for Persistent Pain After Breast Cancer Surgery”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: March 2015

Arms, Groups and Cohorts

  • Study population
    • The study population consists of adult surgery patients, scheduled for breast cancer surgery at St-Luc University Hospital.

Clinical Trial Outcome Measures

Primary Measures

  • Presence of pain 3 months after surgery, assessed with the Brief Pain Inventory questionnaire. Yes/No
    • Time Frame: 3 months

Secondary Measures

  • Acute pain trajectories (7 days) after surgery
    • Time Frame: One postoperative week
    • The pain trajectory is the vector of 7 verbal numerical pain scores (from 0 to 10) recorded in a pain diary over the first 7 postoperative days

Participating in This Clinical Trial

Inclusion Criteria

  • Scheduled for breast cancer surgery
  • General anesthesia

Exclusion Criteria

  • Previous breast surgery
  • Reconstructive surgery scheduled during follow-up
  • Day-surgery patients
  • Inability to understand the questionnaires

Gender Eligibility: Female

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Cliniques universitaires Saint-Luc- Universit√© Catholique de Louvain
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Arnaud Steyaert, MD, Principal Investigator, Cliniques universitaires Saint-Luc

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