Correlation Between the ‘Nine Holes Peg Test’ Performance and the Triple Stimulation Technique Within a Group a Patients With Multiple Sclerosis

Overview

The main goal of this study is to determine if the Triple Stimulation Technique (TST) can be correlated to performance in the manual dexterity 'nine holes peg' test, within a control group and a group of patients with multiple sclerosis. TST (Triple stimulation technique) combines two techniques used in neurologic diagnosis: magnetic stimulation and electroneuromyography. It is based on the principle of two collisions between the descending central stimulation (magnetic stimulation) and the ascending peripheric stimulation. TST allows to better quantify central nervous system diseases. The abnormal amplitude registered by TST is proportional to the intensity of conduction disorders. The evaluation of these disorders is more precise than with the magnetic stimulation technique alone. The Nine Hole Pegs technique is a simple manual dexterity test, commonly used in ergotherapy. The participant tries to place 9 pegs in a 9 holes perforated plate, and then tries to remove them as quickly as possible. The hand must stay in a depression within the plate, thereby insuring a constant distance between the hand and the pegs. The nine hole peg will be realized first, and the triple stimulation examination performed after. The acquired data will be analyzed in order to find a correlation between the impairment level given by these two tests.

Full Title of Study: “Correlation Between the ‘Nine Holes Peg Test’ Performance and the Triple Stimulation Technique Within a Group a Patients With Multiple Sclerosis”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Non-Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Diagnostic
    • Masking: None (Open Label)
  • Study Primary Completion Date: January 30, 2019

Interventions

  • Other: Nine Hole Test
    • The Nine Hole Pegs technique is a simple manual dexterity test, commonly used in ergotherapy. The participant tries to place 9 pegs in a 9 holes perforated plate, and then tries to remove them as quickly as possible. The hand must stay in a depression within the plate, thereby insuring a constant distance between the hand and the pegs.
  • Device: Triple Stimulation Technique
    • TST (Triple stimulation technique) combines two techniques used in neurologic diagnosis: magnetic stimulation and electroneuromyography. It is based on the principle of two collisions between the descending central stimulation (magnetic stimulation) and the ascending peripheric stimulation. TST allows to better quantify central nervous system diseases. The abnormal amplitude registered by TST is proportional to the intensity of conduction disorders. The evaluation of these disorders is more precise than with the magnetic stimulation technique alone.

Arms, Groups and Cohorts

  • Experimental: Multiple sclerosis
    • Patients with multiple sclerosis, followed by Dr Dachy within the CHU Brugmann Hospital.
  • Other: Control group
    • Control group without neurological pathology

Clinical Trial Outcome Measures

Primary Measures

  • Amplitude of the motor evoked potentials
    • Time Frame: during the TST (30 min)
  • Amplitude ratio of the TST
    • Time Frame: during the TST (30 min)
  • Surface ratio of the TST
    • Time Frame: during the TST (30 min)
  • Nine Holes Peg test result
    • Time Frame: Baseline

Participating in This Clinical Trial

Inclusion Criteria

Control group:

  • No history of neurological disease – No medicines intake that could disturb performance within the tests (psychotropic medications, sedatives, anti spastic and drugs acting on neuromuscular transmission). Multiple sclerosis group – Multiple sclerosis diagnose. Patients followed by Dr Dachy, within the CHU Brugmann Hospital. Exclusion Criteria:

  • Persons carrying ferromagnetic material (implants, pacemaker). – Epilepsy history. – Patients who have had a head trauma with loss of consciousness and/or brain injury. – Pregnant woman.

Gender Eligibility: All

Minimum Age: 20 Years

Maximum Age: 60 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Brugmann University Hospital
  • Provider of Information About this Clinical Study
    • Principal Investigator: Bernard Dachy, Head of clinic – Brugmann University Hospital
  • Overall Official(s)
    • Bernard Bernard, MD, Principal Investigator, CHU Brugmann
    • Pedro Calderon, MD, Principal Investigator, CHU Brugmann

References

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