This study investigated whether vitamin D receptor gene polymorphism is altered in primary open-angle glaucoma subjects carrying the risk allele.Primary open-angle glaucoma patients and age-matched people in the Han population were enrolled. Vitamin D receptor polymorphic analysis was studied by polymerase chain reaction-restriction fragment length polymorphism technique.
Full Title of Study: “Associations of Vitamin D Receptor Polymorphisms With the Risk of Primary Open-angle Glaucoma”
- Study Type: Observational
- Study Design
- Time Perspective: Retrospective
- Study Primary Completion Date: December 2014
- Other: Vitamin D receptor polymorphic analysis
Arms, Groups and Cohorts
- primary open-angle glaucoma patients
- vitamin D receptor polymorphic analysis was studied by real-time polymerase-chain reaction high resolution melting analysis in primary open-angle glaucoma patients.
- randomly age-matched people
- vitamin D receptor polymorphic analysis was studied by real-time polymerase-chain reaction high resolution melting analysis in randomly age-matched people.
Clinical Trial Outcome Measures
- gene polymorphisms of vitamin D receptor
- Time Frame: 1 day visit
Participating in This Clinical Trial
- intraocular pressure greater than 22 mmHg with two or more medications wide anterior chamber angle glaucomatous optic neuropathy (Glaucomatous optic nerve damage was defined as cup-to-disc ratio higher than 0.7 or focal loss of the nerve fiber layer (notch) associated with a consistent glaucomatous visual field defect) visual field loss consistent with optic nerve damage and visual fields were performed by using standard automated perimetry
- the presence of any secondary glaucoma including exfoliation syndrome or a history of ocular trauma high myopia macular degeneration other ocular diseases a known history of systemic diseases and administration of vitamin D3 or other analog
Gender Eligibility: All
Minimum Age: 55 Years
Maximum Age: 65 Years
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
- Lead Sponsor
- Lv Yingjuan
- Tianjin Medical University Eye Hospital
- Provider of Information About this Clinical Study
- Sponsor-Investigator: Lv Yingjuan, department of ophthamology – Tianjin Medical University Eye Hospital
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