Respiratory Variability in Aortic Blood Velocity Measured by Suprasternal View as an Indicator of Fluid Responsiveness

Overview

Respiratory changes in aortic blood velocity have been described as an indicator of fluid responsiveness when measured in the left ventricular outflow tract by trans esophageal echography. A threshold value of 12% allowed discrimination between responders and nonresponders with a sensitivity of 100% and a specificity of 89%. The suprasternal window is already used to measure cardiac output. The primary endpoint of this study is to determine the predictive value of the respiratory variability in aortic blood velocity measured by suprasternal view (∆VpicSS) as an indicator of fluid responsiveness. The secondary endpoint is to compare maximum velocity and velocity time integral measured by suprasternal and transthoracic view.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: N/A
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Diagnostic
    • Masking: None (Open Label)
  • Study Primary Completion Date: March 2016

Interventions

  • Device: Fluid challenge with 250 ml of Ringer Lactate
    • Fluid challenge with 250 ml of Ringer Lactate over less than 2 minutes, intra-venous, help by a syringe of 50 ml. Measure of peak velocity before and after the fluid challenge

Arms, Groups and Cohorts

  • Experimental: Fluid challenge with 250 ml of Ringer Lactate

Clinical Trial Outcome Measures

Primary Measures

  • Percentage of cardiac flow variability
    • Time Frame: At day 1(before surgery)
    • Percentage of cardiac flow variability between the 2 echographic measures. Echographic measures will be realized a first time before fluid challenge by suprasternal view and a second time after the fluid challenge by suprasternal view.

Secondary Measures

  • Comparison of percentage of cardiac flow variability between transthoracic and suprasternal views
    • Time Frame: At day 1(before surgery)
    • Echographic measures will be realized a first time before fluid challenge by transthoracic and by suprasternal view and a second time after the fluid challenge by transthoracic and by suprasternal view.

Participating in This Clinical Trial

Inclusion Criteria

  • Age more than 18 years – American Society of Anesthesiologists (ASA) score 1 or 2 – General Anesthesia with mechanical ventilation – General Surgery Exclusion Criteria:

  • Arrhythmia – Spontaneous breathing activity – Significant valvular disease

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Hospices Civils de Lyon
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Pauline Devauchelle, MD, Principal Investigator, Hopital de la Croix-Rousse

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