Effect of Maternal Obesity on Labour Induction in Postdate Pregnancy

Overview

This study investigate the progression of labour in 144 normal weight pregnant women (BMI <30) and 144 obese pregnant women (BMI >30) , not in labor admitted for induction of labor. These women are to be investigated for success of induction of labor.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: May 30, 2017

Detailed Description

– This prospective study will be conducted for 144 obese and 144 non obese ), post date (>41 wks), not in labor. – Woman is classified as obese if BMI >=30. – Prolonged pregnancy was defined as delivery on or after (41+0 weeks) of gestation. – First informed consent will be obtained. – Determination of gestational age – Proper history taking, general and abdominal examinations will be done then digital examination will be performed to determine bishop score. – And obstetric U/S scan will be done and by which the following data will be obtained : – Fetal biometry – Fetal heart activity – Presentation – Localization of the placenta. – Amount of amniotic fluid. – Exclude multifetal pregnancy. – Induction of labor will be done using vaginal misoprostol according to the estimated Bishop score.

Interventions

  • Drug: Misoprostol
    • Misoprostol 25 micrograms every 6 hours will be given to obese and non obese groups

Arms, Groups and Cohorts

  • non obese
    • BMI<30. Misoprostol is given for induction of labour according to Bishop score
  • obese
    • BMI>30. Misoprostol is given for induction of labour according to Bishop score

Clinical Trial Outcome Measures

Primary Measures

  • route of delivery vaginal or caesarean section.
    • Time Frame: 48 hours from the start of induction
    • Partogram is used to access the progress of labour

Secondary Measures

  • maternal haemorrhage
    • Time Frame: 48 hours from the start of induction
    • Calculating number of soaked pads

Participating in This Clinical Trial

Inclusion Criteria

  • Pregnant woman. – Post date >= 41 weeks. – Absent onset of labor. – Patient acceptance to join the study after signing an informed consent. Exclusion Criteria:

  • Placenta previa and or vasa previa. – Previous caesarean section(CS). – Multiple gestation – Any patient who will refuse to be a part of the study. – Intra- uterine fetal death (IUFD).

Gender Eligibility: Female

Minimum Age: 18 Years

Maximum Age: 40 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Kasr El Aini Hospital
  • Provider of Information About this Clinical Study
    • Principal Investigator: heba mahmoud ibrahim marie, lecturer at kaselaini hospitals – Kasr El Aini Hospital
  • Overall Official(s)
    • Heba M Marie, M.D., Principal Investigator, KasrElaini Hospital

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