Chronic Inflammation and Exercise Responsiveness


The purpose of this study is to determine how chronic inflammation influences skeletal muscle protein metabolism and metabolic function in humans. The investigators will evaluate acute responsiveness to a single bout of exercise in men and women who are either lean or overweight/obese. The investigators will explore the relationship between circulating inflammatory markers and anabolic, proteomic, and transcriptional responses to acute exercise. The investigators will measure skeletal muscle protein synthesis in the postabsorptive state and in response to a single bout of exercise.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Cross-Sectional
  • Study Primary Completion Date: December 2022

Arms, Groups and Cohorts

  • Lean
    • Body mass index less than 25 kg/m2
  • Overweight/obese
    • Body mass index 25-45 kg/m2

Clinical Trial Outcome Measures

Primary Measures

  • Maximal oxygen consumption rates in mitochondria isolated from skeletal muscles
    • Time Frame: 1 day

Participating in This Clinical Trial

Inclusion Criteria

  • Age 30-55 years – BMI 19-45 kg/m2 Exclusion Criteria:

  • Anemia (female subjects hemoglobin of <11 g/dl and male subjects hemoglobin <12 g/dl) – Active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment) – Renal insufficiency/failure (serum creatinine > 1.5mg/dl) – Oral warfarin group medications or history of blood clotting disorders. – Pregnancy or breastfeeding – Alcohol consumption greater than 2 glasses/day or other substance abuse – Untreated or uncontrolled thyroid disorders – Debilitating chronic disease (at the discretion of the investigators)

Gender Eligibility: All

Minimum Age: 30 Years

Maximum Age: 55 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Mayo Clinic
  • Provider of Information About this Clinical Study
    • Principal Investigator: Ian R. Lanza, Associate Professor of Medicine – Mayo Clinic
  • Overall Official(s)
    • Ian R Lanza, PhD, Principal Investigator, Mayo Clinic

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