Measuring Auto-fluorescence of White Corpuscles for the Early Diagnosis and the Monitoring of Pneumonia in ICU

Overview

The diagnosis of pneumonia is challenging in Intensive Care Unit. The auto-fluorescence of white corpuscles is altered during pneumonia. In presence of bacterial growth on lung samples, the measure of autofluorescence of white corpuscles could help the clinicians to discriminate bacterial colonization from acute infection.

Full Title of Study: “Measuring Auto-fluorescence of White Corpuscles for the Early Diagnosis and the Monitoring of Pneumonia in Intensive Care Units”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: April 21, 2017

Interventions

  • Other: Autofluorescence of white corpuscle
    • Measure of auto-fluorescence of white corpuscles cells harvested from tracheal aspirate and/or bronchoalveolar lavages

Clinical Trial Outcome Measures

Primary Measures

  • Pneumonia
    • Time Frame: 28 days
    • Diagnosis of pneumonia (Clinical Pulmonary Infection Score > 6, with assessment of the chest radiography by a blinded investigator)

Secondary Measures

  • Clinical Pulmonary Infection Score > 6
    • Time Frame: day 3
  • Acute respiratory distress syndrome
    • Time Frame: day 90
    • PaO2/FiO2 < 200 with a PEEP > 5 (Berlin definition)
  • Duration of mechanical ventilation
    • Time Frame: day 90
  • Intensive Care unit Length of stay
    • Time Frame: day 90
  • Mortality
    • Time Frame: day 90

Participating in This Clinical Trial

Inclusion Criteria

  • Hospitalization in intensive care units – Mechanical ventilation – Age > 18 years – Collection of a lung sample for bacteriological analysis for the suspicion of a first episode of lung infection. Exclusion Criteria:

  • Refuse to participate

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 99 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Nantes University Hospital
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Antoine ROQUILLY, PH, Principal Investigator, Nantes University Hospital

References

Monsel A, Lecart S, Roquilly A, Broquet A, Jacqueline C, Mirault T, Troude T, Fontaine-Aupart MP, Asehnoune K. Analysis of autofluorescence in polymorphonuclear neutrophils: a new tool for early infection diagnosis. PLoS One. 2014 Mar 21;9(3):e92564. doi: 10.1371/journal.pone.0092564. eCollection 2014.

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