Role of K+ and Ca2+ in Development of Muscle Fatigue
Overview
The aim of the study is to investigate the role of K+ and Ca2+ in development of muscle fatigue in trained young men.
Study Type
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Primary Purpose: Basic Science
- Masking: Double (Participant, Investigator)
- Study Primary Completion Date: March 2016
Interventions
- Drug: Terbutaline
- K+ transport and Ca2+ release and uptake function are stimulated by administration of terbutaline
- Drug: Placebo
Arms, Groups and Cohorts
- Active Comparator: terbutaline
- terbutaline is administered by injection (0.25-0.5 mg Bricanyl, AstraZeneca diluted in 9 ml isotonic saline)
- Placebo Comparator: Placebo
- placebo is administered as isotonic saline (10 ml)
Clinical Trial Outcome Measures
Primary Measures
- Change in time to fatigue during knee-extensor exercise
- Time Frame: 1 day
Participating in This Clinical Trial
Inclusion Criteria
- physical active healthy men – aged 18-40 years Exclusion Criteria:
- smokers – allergy towards terbutaline – chronic disease
Gender Eligibility: Male
Minimum Age: 18 Years
Maximum Age: 40 Years
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
Investigator Details
- Lead Sponsor
- University of Copenhagen
- Provider of Information About this Clinical Study
- Principal Investigator: Morten Nielsen, Post.Doc – University of Copenhagen
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