Role of K+ and Ca2+ in Development of Muscle Fatigue

Overview

The aim of the study is to investigate the role of K+ and Ca2+ in development of muscle fatigue in trained young men.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Crossover Assignment
    • Primary Purpose: Basic Science
    • Masking: Double (Participant, Investigator)
  • Study Primary Completion Date: March 2016

Interventions

  • Drug: Terbutaline
    • K+ transport and Ca2+ release and uptake function are stimulated by administration of terbutaline
  • Drug: Placebo

Arms, Groups and Cohorts

  • Active Comparator: terbutaline
    • terbutaline is administered by injection (0.25-0.5 mg Bricanyl, AstraZeneca diluted in 9 ml isotonic saline)
  • Placebo Comparator: Placebo
    • placebo is administered as isotonic saline (10 ml)

Clinical Trial Outcome Measures

Primary Measures

  • Change in time to fatigue during knee-extensor exercise
    • Time Frame: 1 day

Participating in This Clinical Trial

Inclusion Criteria

  • physical active healthy men – aged 18-40 years Exclusion Criteria:

  • smokers – allergy towards terbutaline – chronic disease

Gender Eligibility: Male

Minimum Age: 18 Years

Maximum Age: 40 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • University of Copenhagen
  • Provider of Information About this Clinical Study
    • Principal Investigator: Morten Nielsen, Post.Doc – University of Copenhagen

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