Expression of EPK in Recurrent Miscarriage
Overview
The present study is based on hypotheses that some as yet unknown genetic factors may result in recurrent miscarriage (RM). Consequently, the main aim of this study was to gain new information about the underlying genetic causes of RM in the Egyptian population and to investigate the expression of ERK and p-ERK protein in human placenta and their corresponding tissue, to assess the significance of MAPK signal pathway in progression of recurrent miscarriage and PI3K-Akt Pathway.
Full Title of Study: “MAP Kinase Signaling Pathways Through ERK and p-ERK Protein in Human Placenta of Women With Recurrent Miscarriage”
Study Type
- Study Type: Observational
- Study Design
- Time Perspective: Prospective
- Study Primary Completion Date: December 2015
Interventions
- Other: Investigate the MAP kinase signaling pathways through ERK and p-ERK proteins
Arms, Groups and Cohorts
- Recurrent miscarriage group
- Women with previous history of RM, defined as two or more consecutive miscarriages
- Control group
- Women with no history of RM
Clinical Trial Outcome Measures
Primary Measures
- The levels of ERK and AKT in placenta
- Time Frame: 48 hours
Participating in This Clinical Trial
Inclusion Criteria
1. Gestational age less than 12 weeks. 2. no uterine abnormalities (examined by ultrasonography or hysterosonogram) 3. previous history of RM, defined as two or more consecutive miscarriages Exclusion Criteria:
1. Gestational age 12 weeks or more. 2. Endocrine etiology like (thyroid dysfunction, and uncontrolled diabetes mellitus). 3. Antiphospholipid syndrome, inherited thrombophilias, alloimmune causes. 4. Uterine anatomic anomalies
Gender Eligibility: Female
Minimum Age: 20 Years
Maximum Age: 40 Years
Are Healthy Volunteers Accepted: No
Investigator Details
- Lead Sponsor
- Assiut University
- Provider of Information About this Clinical Study
- Principal Investigator: Ahmed Mohamed Abbas, Dr – Assiut University
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