The Relation Between Serum Ascorbic Acid Concentration and Preterm Premature Rupture of Membranes

Overview

To study the association between maternal serum vitamin C concentration in women with preterm premature rupture of membranes (PPROM) and women without PPROM.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Cross-Sectional
  • Study Primary Completion Date: July 2016

Detailed Description

The micronutrient vitamin C is an effective water soluble antioxidant that scavenges several reactive oxygen species, thus reducing oxidative stress, It also acts as an enzymatic cofactor to the enzymes lysyl hydroxylase and prolyl hydroxylase, which is required for synthesis of hydroxyproline and hydroxylysine, Collagen requires hydroxyproline bridges across the triple helix to provide stability to it, Ascorbic acid also causes down regulation of the metalloproteinase-2 and biosynthesis of collagen where it is required for the formation of triple helical structure of collagen. Thus, ascorbic acid participates in the equilibrium between synthesis and degradation of collagen and this may be critical in reducing the occurrence of preterm PROM.

Arms, Groups and Cohorts

  • study group
    • Study group included 20 pregnant women with PPROM and fulfilled the inclusion and exclusion criteria.
  • control group
    • Control group also included 20 pregnant women without PPROM following every recorded case of PPROM and matched for gestational age.

Clinical Trial Outcome Measures

Primary Measures

  • relation between serum vitamin C concentration and PPROM
    • Time Frame: 6 months

Participating in This Clinical Trial

Inclusion Criteria

  • Singleton pregnancies – Gestational age between 28-37 weeks – Rupture of membranes will be diagnosed by history, sterile speculum examination to confirm fluid leakage from the cervical canal Exclusion Criteria:

  • Patients with multiple pregnancies – Smoker – Polyhydramnios – Maternal diseases such as: anemia, diabetes, UTI, RTI and vaginal infection – History of PPROM in previous pregnancies – Evidence of chorioamnionitis in current pregnancy

Gender Eligibility: Female

Minimum Age: N/A

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Ain Shams Maternity Hospital
  • Provider of Information About this Clinical Study
    • Principal Investigator: Mohamed Hussein Mostafa, Assistant Professor of Obstetric and Gynecology – Ain Shams Maternity Hospital
  • Overall Official(s)
    • Sherif M Habib, MD, Study Director, Professor of Obstetric and Gynecology
  • Overall Contact(s)
    • Mohamed Hu Mostafa, MD, 01003993165, magicmostwanted@yahoo.com

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At TrialBulletin.com, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.