Goldmann Applanation Tonometry, Dynamic Contour Tonometry, and Corvis ST Tonometer

Overview

The study is investigating Intra ocular pressure (IOP) by Goldmann Applanation Tonometry, Dynamic Contour Tonometry, and the Corvis ST tonometer.

Full Title of Study: “Comparison of Intraocular Pressure Measured by Goldmann Applanation Tonometry and Dynamic Contour Tonometry vs. Corvis ST Tonometer”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Non-Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Diagnostic
    • Masking: None (Open Label)
  • Study Primary Completion Date: August 2016

Detailed Description

The aim of the study is to approach the "true" Intra ocular pressure (IOP) by correlating the difference between IOP by Goldmann Applanation Tonometry to the IOP by Dynamic Contour Tonometry to the biomechanical parameters of the cornea measured by Corvis ST. Therefore the investigators gain new findings about the influence of the biomechanical corneal parameters on the IOP. In order to do so the investigators want to examine 50 Glaucoma eyes and 50 non-Glaucoma Eyes with Goldmann Applanation Tonometry, Dynamic Contour Tonometry, and Corvis ST.

Interventions

  • Device: Measurement of intraocular pressure (IOP)
    • Measurement of IOP with the following devices: (1) Goldmann tonometer, (2) Dynamic Contour tonometer, and (3) Corvis ST tonometer

Arms, Groups and Cohorts

  • Experimental: Glaucoma Eyes
    • Measurement of intraocular pressure (IOP)
  • Active Comparator: Healthy Eyes
    • age-matched healthy eyes as controls will undergo Measurement of intraocular pressure (IOP)

Clinical Trial Outcome Measures

Primary Measures

  • Delta IOP
    • Time Frame: baseline
    • IOP difference of Goldmann tonometer and Dynamic Contour tonometer

Secondary Measures

  • Correlation of IOP difference of Goldmann tonometer and Dynamic Contour tonometer with biomechanical corneal properties measured by Corvis ST tonometer
    • Time Frame: baseline
    • Corvis ST has an integrated high-speed Scheimpflug camera which records images on which basis the biomechanical corneal parameter are analyzed (corneal thickness in micrometers, corneal applications in millimeters, peak distance in millimeters, radius in millimeters, and deformation amplitude in millimeters). Those biomechanical parameters of the cornea will be correlated to the difference of the IOP measured by GAT and by DCT (GAT – DCT).

Participating in This Clinical Trial

Inclusion Criteria for the glaucoma group:

  • diagnosis of glaucoma – 18 years old or older with no upper limit Exclusion Criteria for the glaucoma group: – IOP lowering surgery within the last 3 weeks – any corneal surgery in the past – bad fixation – insufficient measurement quality with any of the study devices Inclusion Criteria for the healthy control group: – no diagnosis of glaucoma – 18 years old or older with no upper limit Exclusion Criteria for the healthy control group: – any diagnosis of glaucoma – IOP lowering surgery within the last 3 weeks – any corneal surgery in the past – bad fixation – insufficient measurement quality with any of the study devices

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • University of Zurich
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Jens Funk, MD PhD, Principal Investigator, UniversityHospital of Zurich, Zurich, Switzerland

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