The purpose of this study is to understand the changes in skin microflora, skin barrier function, and skin biochemical constituents in response to direct contact with model surfactants used in personal care articles. The results from this study will provide insights into the complex interaction between the skin microbiome and the epidermis after exposure to surfactants.
- Study Type: Interventional
- Study Design
- Allocation: N/A
- Intervention Model: Single Group Assignment
- Primary Purpose: Basic Science
- Masking: None (Open Label)
- Study Primary Completion Date: December 2015
- Other: PEG-40 Hydrogenated Castor Oil (Tagat CH40, Evonik) 1.5%
- Other: Lauryl glucoside (Plantacare® 1200UP, BASF) 1.5%
- Other: Sorbitan palmitate (SPANTM 40 (powder), Croda) 1.5%
- Other: Silwet* DA-63 (Momentive) 1.5%
- Other: Sodium lauryl sulfate (Sigma Aldrich) 1.0%
- Other: Water (control)
Arms, Groups and Cohorts
- Other: Surfactant Exposure
- PEG-40 Hydrogenated Castor Oil (Tagat CH40, Evonik) 1.5% Lauryl glucoside (Plantacare® 1200UP, BASF) 1.5% Sorbitan palmitate (SPANTM 40 (powder), Croda) 1.5% Silwet* DA-63 (Momentive) 1.5% Sodium lauryl sulfate (Sigma Aldrich) 1.0% Water
Clinical Trial Outcome Measures
- Type of microbes present on skin after exposure to various surfactants
- Time Frame: 4 days
- Microbes will be identified by metagenomic sequencing
- Amount of microbes present on skin after exposure to various surfactants
- Time Frame: 4 days
Participating in This Clinical Trial
- Healthy Subjects with Fitzpatrick Skin Types I, II or III
- Subjects with visible skin disease, tattoos, skin condition, or abnormal skin color
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: 60 Years
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
- Lead Sponsor
- Kimberly-Clark Corporation
- Provider of Information About this Clinical Study
- Overall Official(s)
- Barry Reece, MBA, Principal Investigator, RCTS, Inc.
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