Chemotherapy Followed by Surgery and Neoadjuvant Hemothoracic Intensity Modified Radiation Therapy (IMRT) for Patients With Malignant Pleural Mesothelioma

Overview

The purpose of this study is to determine the response rate and overall survival in patients that have been diagnosed with mesothelioma and will undergo chemotherapy, surgery and intensity modified radiation therapy (IMRT) as part of their standard of care.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: December 2023

Detailed Description

The investigators will consent patients that have been diagnosed with mesothelioma and will undergo chemotherapy followed by surgery and then IMRT as their standard of care. The investigators will collect data from past and future medical records as well as data regarding their health status for their lifetime by reviewing life status, treatment status and CT scans.

Clinical Trial Outcome Measures

Primary Measures

  • Survival status upon review of patients every 6 months
    • Time Frame: 2 years

Secondary Measures

  • Progression free survival as evidenced by CT scan review
    • Time Frame: 2 years

Participating in This Clinical Trial

Inclusion Criteria

  • Subject provides informed consent – Subject is >18 years of age – Subject is deemed competent for making medical decisions – Subject is scheduled to undergo chemotherapy followed by surgery and then IMRT – Subject is a surgical candidate – A negative pregnancy test is required in women of child-bearing potential, as standard of care. Exclusion Criteria:

•Subject is <18 years old.

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Mayo Clinic
  • Provider of Information About this Clinical Study
    • Principal Investigator: Dennis Wigle, Principal Investigator – Mayo Clinic
  • Overall Official(s)
    • Dennis Wigle, MD, PhD, Principal Investigator, Mayo Clinic
  • Overall Contact(s)
    • Karlyn Pierson, RN, 507-293-0807, pierson.karlyn@mayo.edu

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