Outcomes of Severe Osteoporotic Fractures Hospitalized in France: the CROSS Cohort

Overview

The purpose of this study is to determine the outcomes of severe osteoporotic fractures hospitalized in France, the risk of incident severe fracture at 2 years and 5 years and the risk of mortality over 2 and 5 years.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: September 7, 2023

Detailed Description

In France, the burden of osteoporotic fractures has been studied using cross sectional data from the French hospital national database. The availability of fracture liaison service in the main French cities allows the recruitment of a high number of these targeted patients. A large national multicenter, longitudinal, prospective cohort of patients hospitalized for severe osteoporotic fracture, the CROSS cohort ("Cohorte sur les Risques d'une OStéoporose Sévère"), in order to update data on prognosis (refracture, mortality), epidemiology and of severe osteoporotic fractures.

Clinical Trial Outcome Measures

Primary Measures

  • Number of new severe fracture over 2 years
    • Time Frame: 2 years
    • To assess the incidence of new severe fracture over 2 years in patients hospitalized for a severe fracture

Secondary Measures

  • Number of new severe fracture over 5 years
    • Time Frame: 5 years
    • To assess the incidence of new severe fracture over 5 years in patients hospitalized for a severe fracture

Participating in This Clinical Trial

Inclusion Criteria

  • Men and women aged above 60 years, living in France and hospitalized for severe fragility fractures in response to low-energy trauma (e.g., a fall from standing height). – Vertebral fractures have to be confirmed by an X ray examination. – To be eligible for the study the patient has to be included and interviewed within 6 weeks of the fracture event. – Informed and free consent given and form signed and dated Exclusion Criteria:

  • Non severe fracture (for example wrist fracture), pathological fractures, high trauma fractures and per prosthetic fractures. – Non registration with a social security scheme (holder or beneficiary).

Gender Eligibility: All

Minimum Age: 60 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Assistance Publique – Hôpitaux de Paris
  • Collaborator
    • Hospices Civils de Lyon
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Karine BRIOT, MD, PhD, Principal Investigator, Assistance Publique – Hôpitaux de Paris

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