Breath Analysis in Healthy Controls

Overview

The purpose of this study is to detect a specific profile of breath in healthy subjects by an untargeted metabolomic study using exhaled breath analysis by mass spectrometry.

Full Title of Study: “Exhaled Breath Analysis by Secondary Electrospray Ionization (SESI-MS) in Healthy Controls”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: August 2020

Interventions

  • Other: No intervention

Arms, Groups and Cohorts

  • Healthy
    • Healthy subjects with no apparent lung disease and normal lung function testing.

Clinical Trial Outcome Measures

Primary Measures

  • The primary outcome will be the mass spectrometric exhaled breath pattern of healthy subjects.
    • Time Frame: 1 day, single measurement, no follow up

Participating in This Clinical Trial

Inclusion Criteria

1. Normal spirometry (forced expiratory volume in 1 second (FEV1) > 80%, forced vital capacity (FVC) > 80%, FEV1/FVC > 70%.). 2. Age between 18 and 90 years at study entry. Exclusion Criteria:

1. Presence of an active malignancy. 2. Presence of any lung disease (e.g. asthma, chronic obstructive pulmonary disease (COPD), sarcoidosis) 3. Acute inflammatory disease (e.g. common cold) within the last 6 weeks. 4. Acute or chronic hepatic disease. 5. Renal failure or renal replacement therapy.

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 90 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • University of Zurich
  • Collaborator
    • Swiss Federal Institute of Technology
  • Provider of Information About this Clinical Study
    • Sponsor

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