Breath Analysis in Healthy Controls
Overview
The purpose of this study is to detect a specific profile of breath in healthy subjects by an untargeted metabolomic study using exhaled breath analysis by mass spectrometry.
Full Title of Study: “Exhaled Breath Analysis by Secondary Electrospray Ionization (SESI-MS) in Healthy Controls”
Study Type
- Study Type: Observational
- Study Design
- Time Perspective: Prospective
- Study Primary Completion Date: August 2020
Interventions
- Other: No intervention
Arms, Groups and Cohorts
- Healthy
- Healthy subjects with no apparent lung disease and normal lung function testing.
Clinical Trial Outcome Measures
Primary Measures
- The primary outcome will be the mass spectrometric exhaled breath pattern of healthy subjects.
- Time Frame: 1 day, single measurement, no follow up
Participating in This Clinical Trial
Inclusion Criteria
1. Normal spirometry (forced expiratory volume in 1 second (FEV1) > 80%, forced vital capacity (FVC) > 80%, FEV1/FVC > 70%.). 2. Age between 18 and 90 years at study entry. Exclusion Criteria:
1. Presence of an active malignancy. 2. Presence of any lung disease (e.g. asthma, chronic obstructive pulmonary disease (COPD), sarcoidosis) 3. Acute inflammatory disease (e.g. common cold) within the last 6 weeks. 4. Acute or chronic hepatic disease. 5. Renal failure or renal replacement therapy.
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: 90 Years
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
Investigator Details
- Lead Sponsor
- University of Zurich
- Collaborator
- Swiss Federal Institute of Technology
- Provider of Information About this Clinical Study
- Sponsor
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