Airway Responsiveness in Patients With AECOPD Mechanical Ventilation by Inspiratory and Bronchial Dilation Testchronic Obstructive Pulmonary Disease

Overview

In the patients with COPD mechanical ventilation, the bronchial dilatation is very common. However, the evaluation of the efficacy of the medical examination and other subjective indicators, such as doctors, depends on the doctor's experience; at present, there is no objective evaluation index. For patients with mechanical ventilation, the risk of cross infection can not only increase the risk of cross infection, but also increase the workload of clinical doctors and nurses. Therefore, this study proposes an objective evaluation method to evaluate the response of COPD patients to bronchial dilation. The hypothesis of this study can be used to guide the clinical medication through the test of the bronchus. If the patients with bronchial dilation test positive were used in the test, the patients were not used. In this evaluation method, the changes of airway resistance were measured by the accurate measurement of the patients with inhaled bronchial dilatation.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Treatment
    • Masking: None (Open Label)
  • Study Primary Completion Date: October 2016

Interventions

  • Drug: Salbutamol Aerosol
  • Drug: No drugs

Arms, Groups and Cohorts

  • Active Comparator: Atomization inhalation
    • First of all, investigators need to give patients to do the test, the result is more than 12% is positive group, less than 12% is negative group.Second, randomly selected into the atomization group
  • Active Comparator: Without atomization inhalation
    • First of all, investigators need to give patients to do the test, the result is more than 12% is positive group, less than 12% is negative group.Secondly, the random selection is not the atomization group

Clinical Trial Outcome Measures

Primary Measures

  • airway resistance
    • Time Frame: 1 day
    • The first test of bronchial dilatation
  • Respiratory mechanics index:PEEPi
    • Time Frame: 1 day

Secondary Measures

  • Mechanical ventilation time
    • Time Frame: 28 days
  • length of hospital stay
    • Time Frame: 30 days
  • Costs of hospitalization expenses
    • Time Frame: 30 days
  • Routine blood test:Eosinophilic cells
    • Time Frame: 7days

Participating in This Clinical Trial

Inclusion Criteria

  • Acute exacerbation of chronic obstructive pulmonary disease – The mechanical ventilation time of the outdoor endotracheal intubation in the intensive care unit was less than 48 hours Exclusion Criteria:

  • asthma – has received tracheotomy – long term mechanical ventilation (which has been accepted for more than 21 days). – severe pneumonia – Patients who cannot use a patient with bronchial dilation – there's a taboo on the use of a sedative. – refusal to participate in the study – 48 hours to pull out the tube

Gender Eligibility: All

Minimum Age: N/A

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • snow
  • Collaborator
    • Primary-investigator,Bing Sun
  • Provider of Information About this Clinical Study
    • Sponsor-Investigator: snow, – Beijing Chao Yang Hospital
  • Overall Official(s)
    • Bing Sun, Principal Investigator, Beijing Chao Yang Hospital
  • Overall Contact(s)
    • Xue Wang, MB, 0086-10-85231543, rtxue2013@sina.com

References

Li Y, Chen Y, Wang P. Application of impulse oscillometry and bronchial dilation test for analysis in patients with asthma and chronic obstructive pulmonary disease. Int J Clin Exp Med. 2015 Jan 15;8(1):1271-5. eCollection 2015.

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