Energy Expenditure of People Living With HIV/AIDS
Overview
Background: Several studies have reported increased resting energy expenditure (REE) in people living with HIV/AIDS possibly due to changes in body composition that occurs in HIV lipodystrophy syndrome. The aim of this study was to evaluate the influence of the use of lipid-lowering drugs in resting energy expenditure (REE) and total energy expenditure (TEE) in patients seropositive for HIV in treatment of lipodystrophy.
Full Title of Study: “Influence of Lipid-lowering Drugs in Patients Seropositive for HIV With Lipodystrophy in Resting Energy Expenditure and Total Energy Expenditure”
Study Type
- Study Type: Observational
- Study Design
- Time Perspective: Cross-Sectional
- Study Primary Completion Date: June 2014
Detailed Description
REE was measured by indirect calorimetry. TEE was measured by doubly labeled water (DLW) technique and an activity monitor based on accelerometry (AM).
Interventions
- Drug: use of lipid-lowering drugs.
- The patients shoud be in use of a lipid-lowering drugs previouly, at least one month before of the begining of the study.
Arms, Groups and Cohorts
- LIPO-HIPO-
- HIV-seropositive without lipodystrophy and no use of lipid-lowering drugs.
- LIPO+HIPO-
- HIV-seropositive with lipodystrophy and no use of lipid-lowering drugs.
- LIPO+HIPO+
- HIV-seropositive with lipodystrophy and use of lipid-lowering drugs.
Clinical Trial Outcome Measures
Primary Measures
- Total Energy Expenditure (kcal/d)
- Time Frame: 14 day
- Resting Energy Expenditure (kcal/d)
- Time Frame: 1 day
Secondary Measures
- Correlation between doubly labeled water and accelerometer to measure total energy expenditure (ICC, 95% CI)
- Time Frame: 14 days
Participating in This Clinical Trial
Inclusion Criteria
- Use of antiretroviral therapy for at least 4 months – A cluster of differentiation 4 (CD4) T-cell count of >200 cells/mm3 – Use of lipid-lowering drugs for at least 1 month (group HIV-seropositive with lipodystrophy and use of lipid-lowering) Exclusion Criteria:
- Signs or symptoms of opportunistic infections – Thyroid disease
Gender Eligibility: Male
Minimum Age: 18 Years
Maximum Age: 60 Years
Are Healthy Volunteers Accepted: No
Investigator Details
- Lead Sponsor
- University of Sao Paulo General Hospital
- Collaborator
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Provider of Information About this Clinical Study
- Sponsor
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