The Born in Guangzhou Cohort Study (BIGCS)

Overview

The Born in Guangzhou Cohort Study (BIGCS) was established to investigate the short- and long-term effects of exposure in early life on health consequences in Guangzhou, China. Data are collected regarding environmental, occupational and lifestyle exposures as well as health outcomes in later life. Biological samples including blood and tissue samples are also collected from the participants.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: December 31, 2025

Detailed Description

Over the past three decades, China is undergoing rapidly economic development. At the same time, the Western diet and urban lifestyle has been more common than before, which may lead to an increase of incidence of non-communicable chronic diseases, such as diabetes and malignancies. Notably, the current generation of Chinese adults, particularly those in their middle age or older, were born in an era where hardship and rationing was the norm and witnessed a social and epidemiological transition that might have a profound effect on their present health. In contrast, the younger generation is raised in relative material abundance, under the influence of traditional Chinese values such as a strong family orientation and an emphasis on academic success. A birth cohort with would provide an opportunity to examine the short- and long-term effects of exposure in early life on health consequences in this younger generation, in the context of rapid development in China.

Interventions

  • Other: No intervention

Arms, Groups and Cohorts

  • No treatment

Clinical Trial Outcome Measures

Primary Measures

  • Number of participant with pregnancy outcomes
    • Time Frame: At delivery
    • Including abortion, stillbirth, live birth, preterm birth, low birth weight and birth defects

Secondary Measures

  • Neurodevelopment during early childhood
    • Time Frame: At age of 3 years
    • Including adaptive, gross motor, fine motor, language, and social function; assessed using Gesell Developmental Schedules and Ages and Stages Questionnaire
  • Weight changes during early childhood
    • Time Frame: At birth, age of 6 weeks, 6 months, 1 year and 3 years
    • Weight changes from birth, 6 weeks, 6 months, 1 year to 3 years
  • Height changes during early childhood
    • Time Frame: At birth, age of 6 weeks, 6 months, 1 year and 3 years
    • Height changes from birth, 6 weeks, 6 months, 1 year to 3 years
  • Changes of body composition during early childhood
    • Time Frame: At birth, age of 6 weeks, 6 months, 1 year and 3 years
    • Changes of body composition from birth, 6 weeks, 6 months, 1 year to 3 years. Body composition is assessed using Dual Energy X-Ray Absorptiometry

Participating in This Clinical Trial

Inclusion Criteria

  • Pregnant women with <20 weeks of gestation – Pregnant women intended to eventually deliver in Guangzhou Women and Children's Medical Center – Permanent residents or families intended to remain in Guangzhou with their child for ≥3 years

Gender Eligibility: All

Minimum Age: N/A

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Guangzhou Women and Children’s Medical Center
  • Collaborator
    • University of Birmingham
  • Provider of Information About this Clinical Study
    • Principal Investigator: Xiu Qiu, Director of the Born in Guangzhou Cohort Study – Guangzhou Women and Children’s Medical Center
  • Overall Official(s)
    • Xiu Qiu, PhD, Principal Investigator, Guangzhou Women and Children’s Medical Center, China
  • Overall Contact(s)
    • Xiu Qiu, PhD, 0086 20 38367160, qxiu0161@163.com

References

He JR, Yuan MY, Chen NN, Lu JH, Hu CY, Mai WB, Zhang RF, Pan YH, Qiu L, Wu YF, Xiao WQ, Liu Y, Xia HM, Qiu X. Maternal dietary patterns and gestational diabetes mellitus: a large prospective cohort study in China. Br J Nutr. 2015 Apr 28;113(8):1292-300. doi: 10.1017/S0007114515000707. Epub 2015 Mar 30.

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