Practice of Mechanical Ventilation in Patients With Severe Brain Injury in China

Overview

The mechanical ventilation strategy has changed over years worldwide. Several international researches have been conducted to study the association of the use of mechanical ventilation with clinical outcomes. In this prospective, multicenter, cross-sectional survey, the practice of mechanical ventilation among patients with severe brain injury will be investigated in 70 intensive care units in China.

Full Title of Study: “A Survey on the Practice of Mechanical Ventilation Among Patients With Severe Brain Injury in China: a Prospective Observational Study”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Cross-Sectional
  • Study Primary Completion Date: August 2015

Clinical Trial Outcome Measures

Primary Measures

  • Number of patients receiving control and assist mode of mechanical ventilation
    • Time Frame: During 1 hour of on-spot survey
    • Control mode is defined as volume or pressure control ventilation. Assist mode is defined as synchronized intermittent mandatory ventilation and pressure support ventilation.

Secondary Measures

  • The settings of tidal volume, inspiratory pressure, and positive end-expiratory pressure in enrolled patients
    • Time Frame: During 1 hour of on-spot survey
  • Duration of mechanical ventilation
    • Time Frame: 60 days after on-spot survey
  • Number of patients liberated from mechanical ventilation
    • Time Frame: 60 days after on-spot survey
  • Neurological outcome by Glasgow Outcome Scale
    • Time Frame: 60 days after on-spot survey

Participating in This Clinical Trial

Inclusion Criteria

1. older than 18 years

2. with severe brain injury (including severe traumatic brain injury, ischemic stroke, subarachnoid hemorrhage, spontaneous intracerebral hemorrhage, hypoxic-ischemic encephalopathy, intracranial tumor, intracranial infection and idiopathic epilepsy)

3. mechanical ventilated for at least 24 hours before the time of on-spot survey

Exclusion Criteria

1. undergoing a spontaneous breathing trial (SBT) at the time of on-spot survey

2. underwent at least once SBT in the preceding 24 hours before time of on-spot survey

3. enrolled in another trial

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Capital Medical University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Jian-Xin Zhou, Professor – Capital Medical University
  • Overall Official(s)
    • Jian-Xin Zhou, MD, Study Chair, Acute Brain Injury and Critical Care Research Collaboration, ABC Research Collaboration

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