Changes in Volumetric Hemodynamic Parameters Induced by Fluid Removal on Hemodialysis

Overview

Changes in volumetric hemodynamic parameters and fluid overload (Cardiac Index,Stroke Volume, Thoracic Fluid Content, Systemic Vascular Resistance) were measured using a impedance cardiography (ICG) (CardioScreen 1000 – Haemodynamic Measurement System, Medis. GmbH Ilmenau) beginning 15 min prior to midweek dialysis session and continuous measurement thereafter, with a 15-min period after the termination of hemodialysis. Fluid overload were measured by BCM Monitor Fresenius before hemodialysis.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Cross-Sectional
  • Study Primary Completion Date: September 2015

Interventions

  • Device: CardioScreen 1000 – Haemodynamic Measurement System, Medis
    • Impedance cardiography (ICG)
  • Device: BCM- Body Composition Monitor, Fresenius Medical Care
    • Information about the individual fluid status and the nutritional status.
  • Device: SCHILLER, BR-102 plus, Ambulatory Blood Pressure Monitoring System
    • Blood pressure monitoring every 15 min during hemodialysis

Arms, Groups and Cohorts

  • Hemodialysis patients
    • midweek dialysis session patients on maintenance hemodialysis at least 3 months stable dry weight single-pool Kt/V >1.4 no clinical cardiovascular disease during the 6 months preceding entry

Clinical Trial Outcome Measures

Primary Measures

  • Changes in volumetric hemodynamic parameter- cardiac index [l/min/m2]) induced by fluid removal on hemodialysis.
    • Time Frame: 1 day

Secondary Measures

  • Changes in volumetric hemodynamic parameter- stroke volume [ml] induced by fluid removal on hemodialysis.
    • Time Frame: 1 day
  • Changes in volumetric hemodynamic parameter- systemic vascular resistance [dyn·s·cm-5] induced by fluid removal on hemodialysis.
    • Time Frame: 1 day
  • Changes in fluid removal parameter- thoracic fluid content [1/kOhm] during hemodialysis.
    • Time Frame: 1 day
  • Changes in blood pressure values [mmHg] induced by fluid removal on hemodialysis.
    • Time Frame: 1 day

Participating in This Clinical Trial

Inclusion Criteria

  • give voluntary consent to participate in the study – patients on maintenance hemodialysis at least 3 months – stable dry weight – single-pool Kt/V >1.4 – no clinical cardiovascular disease during the 6 months preceding entry Exclusion Criteria:

  • not meet the above criteria – episode of illness (for example: infection) – pregnancy

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Medical University of Warsaw
  • Provider of Information About this Clinical Study
    • Principal Investigator: Łukasz Czyżewski, Łukasz Czyżewski – Medical University of Warsaw
  • Overall Official(s)
    • Janusz Wyzgał, Professor, Study Chair, Medical University of Warsaw, Department of Nephrologic Nursing

References

Czyzewski L, Sanko-Resmer J, Wyzgal J, Kurowski A. Comparative analysis of hypertension and its causes among renal replacement therapy patients. Ann Transplant. 2014 Nov 3;19:556-68. doi: 10.12659/AOT.891248.

Czyzewski L, Wyzgal J, Kolek A. Evaluation of selected risk factors of cardiovascular diseases among patients after kidney transplantation, with particular focus on the role of 24-hour automatic blood pressure measurement in the diagnosis of hypertension: an introductory report. Ann Transplant. 2014 Apr 28;19:188-98. doi: 10.12659/AOT.890189.

Czyzewski L, Sanko-Resmer J, Wyzgal J, Kurowski A. Assessment of health-related quality of life of patients after kidney transplantation in comparison with hemodialysis and peritoneal dialysis. Ann Transplant. 2014 Nov 9;19:576-85. doi: 10.12659/AOT.891265.

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