Desflurane in Children With Laryngeal Mask Airway

Overview

The purpose of this study is to characterize the airway responses to desflurane during maintenance of and emergence from anesthesia in children whose airways were supported with laryngeal mask airways (LMAs).

Full Title of Study: “Sevoflurane Vs. Sevoflurane-desflurane Anesthesia in Children With Laryngeal Mask Airways; Difference in Respiratory Event, Recovery Time and Emergence Agitation”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Prevention
    • Masking: Triple (Participant, Investigator, Outcomes Assessor)
  • Study Primary Completion Date: February 2016

Interventions

  • Drug: Sevoflurane/Desflurane
    • Anesthesia induced with sevoflurane and anesthetic maintenance with desflurane
  • Drug: Sevoflurane
    • Anesthesia induced with sevoflurane and anesthetic maintenance with sevoflurane

Arms, Groups and Cohorts

  • Experimental: Sevoflurane/Desflurane
    • After induction of general anesthesia with sevoflurane, anesthesia was maintained with desflurane.
  • Experimental: Sevoflurane
    • the anesthetic induction and maintenance with sevoflurane.

Clinical Trial Outcome Measures

Primary Measures

  • respiratory adverse events
    • Time Frame: participants will be followed for postoperative period, an expected average of 30 minutes.

Secondary Measures

  • emergence agitation
    • Time Frame: 15 minutes after arrival on PACU

Participating in This Clinical Trial

Inclusion Criteria

  • scheduled for elective surgery under general anesthesia with laryngeal mask airway Exclusion Criteria:

  • history of reactive airways disease with an acute exacerbation within the past 2 weeks – if wheezing or an active upper respiratory infection was present on the day of surgery – if there was a history of malignant hyperthermia – a history of moderate-to-severe hepatic dysfunction following anesthesia with desflurane not otherwise explained.

Gender Eligibility: All

Minimum Age: 2 Years

Maximum Age: 6 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Seoul National University Hospital
  • Provider of Information About this Clinical Study
    • Principal Investigator: Jin-Tae Kim, Professor – Seoul National University Hospital
  • Overall Official(s)
    • JinTae Kim, MD. PhD., Principal Investigator, Seoul National University Hospital

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