The Effect of Carotid IMT (Intima Media Thickness) on Postoperative Cognitive Dysfunction in Patients Undergoing Off-Pump Coronary Artery Bypass Graft Surgery
Overview
The patients who have undergone cardiac surgery have higher likelihood of postoperative cognitive dysfunction (POCD). The carotid intima-media thickness (IMT) is associated with cognitive dysfunction in the old. The aim of this study is to evaluate the effect of carotid IMT in patients undergoing OPCAB(off-pump coronary artery bypass surgery) on postoperative cognitive dysfunction. Two hundred twenty four patients, aged 20 to 79 years, scheduled for OPCAB will be divided into increased IMT (n=112) and normal IMT (n=112) group by preoperative B-mode ultrasonography. The cognitive function measured by K-MMSE, MOCA-K before the operation, and on the 7 day, 3 months after operation. The patients in the non-surgical group are measured three times: baseline, after 7days, after 3 months.
Study Type
- Study Type: Observational
- Study Design
- Time Perspective: Prospective
- Study Primary Completion Date: April 8, 2019
Arms, Groups and Cohorts
- increased carotid IMT group
- Patients who have increased carotid IMT (intima media thickness)
- normal carotid IMT group
- Patients who have normal carotid IMT
Clinical Trial Outcome Measures
Primary Measures
- postoperative cognitive dysfunction
- Time Frame: 7 days after surgery
Participating in This Clinical Trial
Inclusion Criteria
- patients who are scheduled to undergo OPCAB Exclusion Criteria:
- severe cognitive dysfunction – disabling mental change disorder – unable to communicate or speak Korean – do not have carotid IMT measurement.
Gender Eligibility: All
Minimum Age: 60 Years
Maximum Age: N/A
Are Healthy Volunteers Accepted: No
Investigator Details
- Lead Sponsor
- Yonsei University
- Provider of Information About this Clinical Study
- Sponsor
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