The Effect of Carotid IMT (Intima Media Thickness) on Postoperative Cognitive Dysfunction in Patients Undergoing Off-Pump Coronary Artery Bypass Graft Surgery

Overview

The patients who have undergone cardiac surgery have higher likelihood of postoperative cognitive dysfunction (POCD). The carotid intima-media thickness (IMT) is associated with cognitive dysfunction in the old. The aim of this study is to evaluate the effect of carotid IMT in patients undergoing OPCAB(off-pump coronary artery bypass surgery) on postoperative cognitive dysfunction. Two hundred twenty four patients, aged 20 to 79 years, scheduled for OPCAB will be divided into increased IMT (n=112) and normal IMT (n=112) group by preoperative B-mode ultrasonography. The cognitive function measured by K-MMSE, MOCA-K before the operation, and on the 7 day, 3 months after operation. The patients in the non-surgical group are measured three times: baseline, after 7days, after 3 months.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: April 8, 2019

Arms, Groups and Cohorts

  • increased carotid IMT group
    • Patients who have increased carotid IMT (intima media thickness)
  • normal carotid IMT group
    • Patients who have normal carotid IMT

Clinical Trial Outcome Measures

Primary Measures

  • postoperative cognitive dysfunction
    • Time Frame: 7 days after surgery

Participating in This Clinical Trial

Inclusion Criteria

  • patients who are scheduled to undergo OPCAB Exclusion Criteria:

  • severe cognitive dysfunction – disabling mental change disorder – unable to communicate or speak Korean – do not have carotid IMT measurement.

Gender Eligibility: All

Minimum Age: 60 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Yonsei University
  • Provider of Information About this Clinical Study
    • Sponsor

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