CHildhood ASthma and Environment Research Study – CHASER Study

Overview

"CHildhood ASthma and Environment Research study – CHASER study" is an observational longitudinal study in outpatient clinic of Pediatric Allergology & Pulmonology (PAP) of Respiratory Disease Research Center (RDRC) within the Institute of Biomedicine and Molecular Immunology (IBIM) of the National Research Council (CNR) of Palermo (RDRC-IBIM CNR), Italy. The first phase – transversal study will identify determinants of pediatric asthma control The second phase – longitudinal study, in patients with persistent asthma, will be focused on: – predictors for asthma exacerbations and loss of control – real life adherence to asthma therapy guidelines – phenotypic characterization through the collection of saliva samples – assessment of alterations and inflammatory changes in the nasal mucosa through nasal brushing – evaluation of the presence of 8-isoprostane, nicotine, cotinine and bisphenol-A through urine analysis. Chaser Project is expected to improve the knowledge of pediatric asthma in patients with different level of control, identifying predictors for asthma exacerbations and loss of control.

Full Title of Study: “CHildhood ASthma and Environment Research Study – CHASER Study”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: December 2022

Clinical Trial Outcome Measures

Primary Measures

  • Asthma
    • Time Frame: 5 years

Secondary Measures

  • Measures from saliva samples
    • Time Frame: 5 years
  • Measures from nasal brushing
    • Time Frame: 5 years
  • Measures from urine samples
    • Time Frame: 5 years

Participating in This Clinical Trial

Inclusion Criteria

  • age 5-16 years – asthma – not asthma Exclusion Criteria:

  • chest deformity – active smoking

Gender Eligibility: All

Minimum Age: 5 Years

Maximum Age: 16 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Stefania La Grutta, MD
  • Provider of Information About this Clinical Study
    • Sponsor-Investigator: Stefania La Grutta, MD, Stefania La Grutta, MD. Senior Researcher. Coordinator of Pediatric Allergy and Asthma Research Group. Institute of Biomedicine and Molecular Immunology, IBIM, National Research Council of Palermo, Italy. – Istituto per la Ricerca e l’Innovazione Biomedica
  • Overall Contact(s)
    • Stefania La Grutta, MD, +39-091-6809680, stefania.lagrutta@irib.cnr.it

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