Effect of Ursolic Acid of Loquat Extract on Function of Muscle

Overview

This randomized, placebo-controlled, double-blind study was designed to investigate the efficacy and tolerability of Ursolic Acid of Loquat Extract for treatment of muscle function improvement with relatively health adults. 54 subjects received 500 mg of Loquat Extract per day or a placebo for 12 weeks.

Full Title of Study: “Effect of Ursolic Acid of Loquat Extract on Function of Muscle in Human”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Prevention
    • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Study Primary Completion Date: February 2015

Detailed Description

This randomized, placebo-controlled, double-blind study was designed to investigate the efficacy and tolerability of Ursolic Acid of Loquat Extract for treatment of muscle function improvement with relatively health adults. 54 subjects received 500 mg of Loquat Extract per day or a placebo for 12 weeks. Change over time in muscle fuction was evaluated by four outcomes: assessment of appendicular skeletal mass using DEXA (dual energy X-ray absorptiometry); quadriceps muscle power by Biodex; hand grib power; and Short Physical Performance Battery, SPPB.

Interventions

  • Dietary Supplement: UA group
    • Ursolic Acid of Loquat Extract, 500mg/ day during 12 weeks

Arms, Groups and Cohorts

  • Experimental: UA group
    • UA group who takes Ursolic acid of Loquat Extract , 500 mg/ day during 12 weeks for treatment of muscle function improvement with relatively health adults
  • Placebo Comparator: placebo group
    • placebo group who takes a placebo, 500 mg/day for 12 weeks

Clinical Trial Outcome Measures

Primary Measures

  • quadriceps muscle function
    • Time Frame: 12weeks

Secondary Measures

  • ASM(appendicular skeletal mass) marker
    • Time Frame: 12weeks
  • Short Physical Performance Battery, SPPB
    • Time Frame: 12weeks

Participating in This Clinical Trial

Inclusion Criteria

  • BMI 18.5-30KG/M2 Exclusion Criteria:

  • > SERUM creatinine 1.2mg/dL – > AST or ALT 60IU/L – DM Patients

Gender Eligibility: All

Minimum Age: 19 Years

Maximum Age: 65 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Pusan National University Hospital
  • Provider of Information About this Clinical Study
    • Principal Investigator: Sang Yeoup Lee, family medicine – Pusan National University Hospital
  • Overall Official(s)
    • SANG YEOUP Lee, Pf., Principal Investigator, Pusan National University Yangsan Hospital

Citations Reporting on Results

Prissadova N, Bozov P, Marinkov K, Badakov H, Kristev A. Effects of ursolic acid on contractile activity of gastric smooth muscles. Nat Prod Commun. 2015 Apr;10(4):565-6.

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