An Analysis of Presentation and Outcome Following Treatment of Pancreatic Endocrine Neoplasms

Overview

A single institutional study of Pancreatic Endocrine Neoplasms over 18 years.

Full Title of Study: “A Single Centre Analysis of Clinical Characteristics and Treatment of Endocrine Pancreatic Tumours.”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: June 2011

Detailed Description

The investigators did an analysis from a prospectively maintained database of patients who underwent pancreatic resections or nonresective procedures for neoplasms of the pancreas at Sir Ganga Ram Hospital from 1995 to 2013 and using pathological reports and preoperative CT scan as the gold standard, the investigators identified 40 patients with PENs.

Arms, Groups and Cohorts

  • Pancreatic Endocrine Neoplasms
    • We did an observational analysis from a prospectively maintained database of patients who underwent pancreatic surgery for neoplasms of the pancreas at Sir Ganga Ram Hospital, New Delhi, India from 1995 to 2013 and using pathological reports and preoperative CT scan as gold standard, we identified 40 patients with PENs.

Clinical Trial Outcome Measures

Primary Measures

  • Nonfunctioning and Malignant Pancreatic Endocrine Neoplasms
    • Time Frame: Each participant was followed up for a period of 5 years
    • Of the 40 patients operated for Pancreatic Endocrine Neoplasms, using clinical criteria, histopathological analysis and preoperative imaging as gold standard, nonfunctioning and functioning tumours were identified. Similarly the number of benign and malignant lesions identified were recorded as per the WHO Classification of pancreatic endocrine tumours.

Participating in This Clinical Trial

Inclusion Criteria

  • Pathological reports and Prooperative CAT Scan showing Endocrine Pancreatic Tumours

Exclusion Criteria

  • Nonendocrine Pancreatic Tumours

Gender Eligibility: All

Minimum Age: N/A

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Medical College and Hospital Kolkata
  • Collaborator
    • Sir Ganga Ram Hospital
  • Provider of Information About this Clinical Study
    • Principal Investigator: Md Tanveer Adil, Fellow – Sir Ganga Ram Hospital
  • Overall Official(s)
    • Md Tanveer Adil, Principal Investigator, Sir Ganga Ram Hospital, New Delhi
    • Raghavendra Nagaraja, Study Director, Sir Ganga Ram Hospital, New Delhi
    • Vibha Varma, Study Director, Sir Ganga Ram Hospital, New Delhi
    • Naimish Mehta, Study Director, Sir Ganga Ram Hospital, New Delhi
    • Vinay Kumaran, Study Director, Sir Ganga Ram Hospital, New Delhi
    • Samiran Nundy, Study Chair, Sir Ganga Ram Hospital, New Delhi

References

Vortmeyer AO, Huang S, Lubensky I, Zhuang Z. Non-islet origin of pancreatic islet cell tumors. J Clin Endocrinol Metab. 2004 Apr;89(4):1934-8.

Halfdanarson TR, Rabe KG, Rubin J, Petersen GM. Pancreatic neuroendocrine tumors (PNETs): incidence, prognosis and recent trend toward improved survival. Ann Oncol. 2008 Oct;19(10):1727-33. doi: 10.1093/annonc/mdn351. Epub 2008 May 30.

Citations Reporting on Results

Kazanjian KK, Reber HA, Hines OJ. Resection of pancreatic neuroendocrine tumors: results of 70 cases. Arch Surg. 2006 Aug;141(8):765-9; discussion 769-70.

Vagefi PA, Razo O, Deshpande V, McGrath DJ, Lauwers GY, Thayer SP, Warshaw AL, Fernández-Del Castillo C. Evolving patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms: the Massachusetts General Hospital experience from 1977 to 2005. Arch Surg. 2007 Apr;142(4):347-54.

Heitz PU, Komminoth P, Perrin A et al. Pancreatic endocrine tumors: Introduction. In: DeLellis DA, Lloyd RV, Heitz PU, et al., eds. Pathology and Genetics of Tumours of Endocrine Organs. WHO Classification of Tumours. Lyon, France: IARC Press, 2004: 177-82.

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