Renal Tubular Acidosis is Highly Prevalent in Critically Ill Patients
Overview
The aim of this study was to investigate the prevalence, type, and possible risk factors of RTA in critically ill patients using a physical-chemical approach.
Study Type
- Study Type: Observational
- Study Design
- Time Perspective: Prospective
- Study Primary Completion Date: October 2011
Detailed Description
Hyperchloremic acidosis is frequent in critically ill patients. Renal tubular acidosis (RTA) may contribute to acidemia in the state of hyperchloremic acidosis, but the prevalence of RTA has never been studied in critically ill patients. Therefore, we aimed to investigate the prevalence, type, and possible risk factors of RTA in critically ill patients using a physical-chemical approach. This prospective, observational trial was conducted in a medical ICU of a university hospital. 100 consecutive critically ill patients at the age ≥18, expected to stay in the ICU for ≥24h, with the clinical necessity for a urinary catheter and the absence of anuria were included. Base excess subset calculation based on a physical-chemical approach on the first seven days after ICU admission was used to compare the effects of free water, chloride, albumin, and unmeasured anions on the standard base excess. Calculation of the urine osmolal gap (UOG) - as an approximate measure of the unmeasured urine cation ammonium – served as determinate between renal and extra-renal bicarbonate loss in the state of hyperchloremic acidosis.
Arms, Groups and Cohorts
- critically ill patients
- critically ill patients at the age ≥18, expected to stay in the ICU for ≥24h, with the clinical necessity for a urinary catheter and the absence of anuria
Clinical Trial Outcome Measures
Primary Measures
- renal-tubular acidosis
- Time Frame: up to 7 days after ICU admission
- Diagnosis of renal-tubular acidosis in critically ill patients within 7 days after ICU admission.
Participating in This Clinical Trial
Inclusion Criteria
- admitted to the medical ICU of the Div. of Gastroenterology & Hepatology of the Medical University of vienna – age ≥18 – expectancy to stay in the ICU ≥24hours – clinical necessity for a urinary catheter Exclusion Criteria:
- anuria
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: N/A
Are Healthy Volunteers Accepted: No
Investigator Details
- Lead Sponsor
- Medical University of Vienna
- Provider of Information About this Clinical Study
- Principal Investigator: Richard Brunner, MD, Dr – Medical University of Vienna
- Overall Official(s)
- Richard Brunner, MD, Principal Investigator, Medical University of Vienna
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