Cocaine-use disorders continue to be a significant public health concern, yet no effective medications have been identified. The goal of this study is to establish a research platform for the development of medications for treatment of cocaine abuse and dependence. This study will incorporate choice self-administration procedures between drug and a non-drug alternative reinforcer presented during maintenance on d-amphetamine, which has been previously shown to reduce cocaine use.
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Primary Purpose: Basic Science
- Masking: Double (Participant, Outcomes Assessor)
- Study Primary Completion Date: April 5, 2018
- Drug: Cocaine
- Drug: Sustained Release d-Amphetamine
Arms, Groups and Cohorts
- Experimental: Active Treatment
- Cocaine choice during d-amphetamine maintenance
- Placebo Comparator: Placebo Treatment
- Cocaine choice during placebo maintenance
Clinical Trial Outcome Measures
- The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative
- Time Frame: 9 choice trials per cocaine dose level with each trial separated by 30 minutes
- The reinforcing effects of cocaine were determined using a modified progressive ratio procedure (Lile et al., 2016) in which subjects made 9 choices between each available cocaine dose and money (US$6.00). Reinforcing effects are measured for each cocaine dose during both d-amphetamine and placebo maintenance.
Participating in This Clinical Trial
- Recent cocaine use, otherwise healthy Exclusion Criteria:
- Laboratory results outside of clinically acceptable ranges, history of or current serious physical or psychiatric disease
Gender Eligibility: All
Minimum Age: 21 Years
Maximum Age: 45 Years
Are Healthy Volunteers Accepted: No
- Lead Sponsor
- Joshua A. Lile, Ph.D.
- Provider of Information About this Clinical Study
- Sponsor-Investigator: Joshua A. Lile, Ph.D., Joshua A. Lile, Ph.D., Associate Professor of Behavioral Science – University of Kentucky
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