Effects of Isoflavone Combined With Astaxanthin on Skin Aging
Overview
Photoaging is caused by the superposition of chronic ultraviolet (UV)-induced damage on the intrinsic aging process, and accounts for the majority of age-associated changes in skin appearance. Reactive oxygen species (ROS) play a key role in UV-induced skin damage and diminish skin matrix protein levels, leading skin aging. Strategies utilizing endogenous skin antioxidants as well as plant-derived or synthetic compounds have been examined. Astaxanthin mainly from marine algae and crustaceans is a kind of carotenoids which were well-known photo-protective agents with strong antioxidant activity. Several studies have revealed that supplementation of astaxanthin effectively protect skin against UV damage through free radicals. In addition, matrix metalloproteinase-1 induced by UV irradiation is an important step toward skin aging. Recently, many studies pointed out that phytoestrogens exhibit agonistic and antagonistic estrogen activities, suppressing activity of MMP-1 in skin. Isoflavone is a kind of phytoestrogen from soybean and mainly act on skin and bones, inhibiting MMP-1 effectively. The present study is designed to take isoflavone combined with astaxanthin to maximize their anti-aging ability and objectively measure the effects of the mixture on facial wrinkles, hydration, and elasticity.
Study Type
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Primary Purpose: Treatment
- Masking: Double (Participant, Investigator)
- Study Primary Completion Date: November 2015
Interventions
- Dietary Supplement: Isoflavone
- Dietary Supplement: Astaxanthin
- Dietary Supplement: Placebo
Arms, Groups and Cohorts
- Active Comparator: Isoflavone and Astaxanthin
- Each subject takes one active tablet per day for 24 weeks. Each tablet contains isoflavone 27mg and astaxanthin 4mg.
- Placebo Comparator: Placebo
- Each subject takes one placebo tablet per day for 24 weeks.
Clinical Trial Outcome Measures
Primary Measures
- Change from baseline in skin wrinkles
- Time Frame: Twenty-four weeks
- Facial wrinkles in the crow’s feet area measured by Skin Visiometer
Secondary Measures
- Change from baseline in skin elasticity
- Time Frame: Twenty-four weeks
- Facial elasticity measured by Cutometer
- Change from baseline in epidermal hydration
- Time Frame: Twenty-four weeks
- Skin hydration measured by Corneometer
- Change from baseline in skin barrier integrity
- Time Frame: Tewnty-four weeks
- TEWL measured by Tewameter
Participating in This Clinical Trial
Inclusion Criteria
- Healthy females aged ≥ 45 years – Facial wrinkle grade 2 to 4 Exclusion Criteria:
- received medical or cosmetic treatment that interferes with the general aging process at least 3 months before the study – received any hormone replacement therapy at least 3 months before the study – reported taking functional foods more than 1 month during last 3 months before the study – history of acute or chronic disease such as severe liver or kidney disease – history of allergies against any component of trial foods – any visible skin disease that might be confused with a skin reaction to the test procedure
Gender Eligibility: Female
Minimum Age: 45 Years
Maximum Age: N/A
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
Investigator Details
- Lead Sponsor
- Seoul National University Hospital
- Provider of Information About this Clinical Study
- Principal Investigator: Jin Ho Chung, Professor – Seoul National University Hospital
- Overall Official(s)
- Jin Ho Chung, MD, PhD, Principal Investigator, Seoul National University Hospital
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