Effects of Isoflavone Combined With Astaxanthin on Skin Aging

Overview

Photoaging is caused by the superposition of chronic ultraviolet (UV)-induced damage on the intrinsic aging process, and accounts for the majority of age-associated changes in skin appearance. Reactive oxygen species (ROS) play a key role in UV-induced skin damage and diminish skin matrix protein levels, leading skin aging. Strategies utilizing endogenous skin antioxidants as well as plant-derived or synthetic compounds have been examined. Astaxanthin mainly from marine algae and crustaceans is a kind of carotenoids which were well-known photo-protective agents with strong antioxidant activity. Several studies have revealed that supplementation of astaxanthin effectively protect skin against UV damage through free radicals. In addition, matrix metalloproteinase-1 induced by UV irradiation is an important step toward skin aging. Recently, many studies pointed out that phytoestrogens exhibit agonistic and antagonistic estrogen activities, suppressing activity of MMP-1 in skin. Isoflavone is a kind of phytoestrogen from soybean and mainly act on skin and bones, inhibiting MMP-1 effectively. The present study is designed to take isoflavone combined with astaxanthin to maximize their anti-aging ability and objectively measure the effects of the mixture on facial wrinkles, hydration, and elasticity.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Treatment
    • Masking: Double (Participant, Investigator)
  • Study Primary Completion Date: November 2015

Interventions

  • Dietary Supplement: Isoflavone
  • Dietary Supplement: Astaxanthin
  • Dietary Supplement: Placebo

Arms, Groups and Cohorts

  • Active Comparator: Isoflavone and Astaxanthin
    • Each subject takes one active tablet per day for 24 weeks. Each tablet contains isoflavone 27mg and astaxanthin 4mg.
  • Placebo Comparator: Placebo
    • Each subject takes one placebo tablet per day for 24 weeks.

Clinical Trial Outcome Measures

Primary Measures

  • Change from baseline in skin wrinkles
    • Time Frame: Twenty-four weeks
    • Facial wrinkles in the crow’s feet area measured by Skin Visiometer

Secondary Measures

  • Change from baseline in skin elasticity
    • Time Frame: Twenty-four weeks
    • Facial elasticity measured by Cutometer
  • Change from baseline in epidermal hydration
    • Time Frame: Twenty-four weeks
    • Skin hydration measured by Corneometer
  • Change from baseline in skin barrier integrity
    • Time Frame: Tewnty-four weeks
    • TEWL measured by Tewameter

Participating in This Clinical Trial

Inclusion Criteria

  • Healthy females aged ≥ 45 years – Facial wrinkle grade 2 to 4 Exclusion Criteria:

  • received medical or cosmetic treatment that interferes with the general aging process at least 3 months before the study – received any hormone replacement therapy at least 3 months before the study – reported taking functional foods more than 1 month during last 3 months before the study – history of acute or chronic disease such as severe liver or kidney disease – history of allergies against any component of trial foods – any visible skin disease that might be confused with a skin reaction to the test procedure

Gender Eligibility: Female

Minimum Age: 45 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Seoul National University Hospital
  • Provider of Information About this Clinical Study
    • Principal Investigator: Jin Ho Chung, Professor – Seoul National University Hospital
  • Overall Official(s)
    • Jin Ho Chung, MD, PhD, Principal Investigator, Seoul National University Hospital

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