Effect of Phosphorus Supplementation on Body Weight

Overview

Phosphorus is a mineral that is naturally present in our foods and is required by our bodies for normal function. It has been found that phosphorus supplementation taken before meals has the potential to reduce meal size. However its long term effect has not been measured yet. It is well accepted that changes in body weight require about 3 months. Using body weight as the outcome, which is the ultimate outcome of weight loss approaches, would provide robust information on the role of phosphorus.

Full Title of Study: “Premeal Phosphorus Supplementation for Reducing Energy Intake and Body Weight”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Basic Science
    • Masking: Double (Participant, Investigator)
  • Study Primary Completion Date: June 2014

Detailed Description

A double-blind, randomised, placebo-controlled trial of 63 adults aged 18 to 45 years with a body mass index (BMI) of 25 kg/m2 or higher and normal kidney function at the American University of Beirut. Participants were randomly assigned to the placebo or phosphorus group where daily placebo or phosphorus supplements were ingested with three main meals (breakfast, lunch, and dinner) for a period of 12 weeks. Primary outcomes were changes in anthropometric measures, blood metabolites (including lipid profile, glucose, and insulin), and subjective appetite scores.

Interventions

  • Dietary Supplement: phosphorus
    • phosphorus supplement

Arms, Groups and Cohorts

  • Active Comparator: phosphorus
    • phosphorus ingestion (375mg) with each main meal ( breakfast, lunch, dinner)
  • Placebo Comparator: placebo
    • ingestion of placebo tablets with each meal ( breakfast, lunch, dinner)

Clinical Trial Outcome Measures

Primary Measures

  • Body Weight
    • Time Frame: 3 months

Secondary Measures

  • Waist Circumference
    • Time Frame: 3 months
  • Appetite Score on the Visual Analog Scale
    • Time Frame: 6 weeks

Participating in This Clinical Trial

Inclusion Criteria

  • BMI>25
  • CR>1mg/dl for women; Cr >1.2 mg/dl for men
  • GFR >60ml/min/1.73m2

Exclusion Criteria

  • BMI<25
  • presence of any significant medical disease,
  • pregnancy or lactation,
  • regular administration of drugs that affect body weight, and
  • weight loss of 3% or more within 3 months of study entry.

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 45 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • American University of Beirut Medical Center
  • Provider of Information About this Clinical Study
    • Principal Investigator: Omar Obeid, professor – American University of Beirut Medical Center
  • Overall Official(s)
    • Omar Obeid, PhD, Principal Investigator, AUB

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At TrialBulletin.com, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.