Genetic Analysis of Childhood Obesity

Overview

Identify news genetic causes of different type of obesity (syndromic, familial or isolated obesity) by highlighting new mutations or new implied genes

Study Type

• Study Type: Observational
• Study Design
  • Time Perspective: Prospective
• Study Primary Completion Date: December 2020

Interventions

• Other: Identification of genetic causes of obesity
  • A blood test will be performed to the child and his/her parents with the aim of identifying genetic causes of obesity. Different analysis will be as follows: caryotypes, Raindance, whole exome, in order to find potential mutations or new genes associated to this condition

Arms, Groups and Cohorts

• Syndromic obesity
  • Identification of genetic causes of obesity
• Familial obesity
  • Identification of genetic causes of obesity
• Isolated obesity
  • Identification of genetic causes of obesity

Clinical Trial Outcome Measures

Primary Measures

• To identify the number of mutations or genes involved in genetic causes of Child obesity
  • Time Frame: first day of enrollement
  • Children with obesity and their parents will be recruited to establish genetic causes of obesity. This will allow perform genetic analysis using new approaches for the identification of involved mutations or new candidate genes

Secondary Measures

• To identify the number of mutations in the population
  • Time Frame: first day of enrollement
• To identify the number of new mutations present in the children’s DNA and absent from their parents’ genomes
  • Time Frame: first day of enrollement
  • This approach will allow the identification of specific mutations that are present only in affected children but not in their parents
• To determine number of phenotypes associated to the child obesity genotype
  • Time Frame: first day of enrollement

Participating in This Clinical Trial

Inclusion Criteria

• BMI > curve of IOTF 30 (International Obesity Task Force) – Age: between 6 months old and 18 years old – Child presenting syndromic, isolated or familial obesity. Exclusion Criteria:

• Common obesity – Impossibility for blood sampling – Impossibility to receive information – Participation refusal of one of the parents – Refusal to sign the informed consent – Neither Healthcare coverage nor insurance

Gender Eligibility: All

Minimum Age: 6 Months

Maximum Age: 18 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

• Lead Sponsor
  • Lille Catholic University
• Collaborator
  • Institut Pasteur de Lille
• Provider of Information About this Clinical Study
  • Sponsor
• Overall Official(s)
  • Louise Montagne, Principal Investigator, Groupement des Hôpitaux de l’Institut Catholique de Lille
  • Philippe Froguel, MD, PhD, Principal Investigator, UMR CNRS 8199, Institut Pasteur de Lille
• Overall Contact(s)
  • Amélie Lansiaux, MD, PhD, lansiaux.amelie@ghicl.net