Utility of Urinary beta2 Microglobulin as an Early Marker of Renal Dysfunction in Vietnamese HIV-Infected Patients
Overview
This study is to investigate clinical utility of beta2 microglobulin as an early marker for renal dysfunction caused by Tenofovir in Vietnamese HIV-infected patients.
Full Title of Study: “Vietnam-Japan Cooperative Research on Prognosis of HIV-1-infection -Clinical Utility of Urinary beta2 Microglobulin as an Early Marker of Renal Dysfunction Caused by Use of Tenofovir in Vietnamese HIV-Infected Patients-“
Study Type
- Study Type: Observational
- Study Design
- Time Perspective: Prospective
- Study Primary Completion Date: November 2016
Detailed Description
An observational study to investigate clinical utility of beta2 microglobulin as an early marker for renal dysfunction caused by Tenofovir in Vietnamese HIV-infected patients.
Clinical Trial Outcome Measures
Primary Measures
- Evaluation of urinary beta2microglobulin, urinary protein and serum creatinine among Vietnamese HIV-infected patients
- Time Frame: 3 years
- Follow up Vietnamese HIV-infected patients, for their renal function including urinary beta2microglobulin, urinary protein and serum creatinine for 3 years
Secondary Measures
- Evaluation of risk factors for renal dysfunction and tubular dysfunction
- Time Frame: 3 years
- Risk factors for renal and tubular dysfunction were evaluated. Risk factors including: Age, sex, body weight, history of ART, AIDS or non-AIDS complication and concomitant use of cotrimoxazole, Hepatitis C virus antibody and Hepatitis B virus Ag antigen, CD4 positive cell count and HIV viral load.
Participating in This Clinical Trial
Inclusion Criteria
- HIV-infected patients in the NHTD -ACC cohort who are under cART or will start cART and can provide written informed consents. Exclusion Criteria:
- HIV-infected patients who drop out of treatment within 6 months from the entry.
Gender Eligibility: All
Minimum Age: 20 Years
Maximum Age: N/A
Are Healthy Volunteers Accepted: No
Investigator Details
- Lead Sponsor
- National Center for Global Health and Medicine, Japan
- Provider of Information About this Clinical Study
- Sponsor
- Overall Official(s)
- Shinichi Oka, MD. PhD, Principal Investigator, National Center for Global Health and Medicine
Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.