The Impact of Riboflavin on the Severity and Duration of Sports Related Concussion


The purpose of this study is to investigate the effectiveness of riboflavin to decrease the duration of time for a student-athlete to return to participation in sports after a sports related concussion.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: N/A
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Treatment
    • Masking: None (Open Label)
  • Study Primary Completion Date: August 2015


  • Drug: Riboflavin 400mg daily

Arms, Groups and Cohorts

  • Experimental: Riboflavin

Clinical Trial Outcome Measures

Primary Measures

  • Time to return to full participation in sports after a sports related concussion
    • Time Frame: 21 days or less

Participating in This Clinical Trial

Inclusion Criteria

  • All UVa and JMU student-athletes over the age of 18 years old who are diagnosed with a sports related concussion Exclusion Criteria:

  • Less than 18 years old – Greater than 24 hours have elapsed since the concussion occurred. – The student-athlete has already participated in the study during which he/she took Riboflavin – Non-sports related concussion not incurred while participating in the sport or training for the sport. As an example, a student-athlete who sustains a concussion as a result of a motor vehicle accident will be excluded from the study for that concussion

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • University of Virginia
  • Collaborator
    • James Madison University
  • Provider of Information About this Clinical Study
    • Principal Investigator: Jeremy Kent, MD, Assistant Professor – University of Virginia


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