The purpose of this study is to investigate the role of erythromycin, a prokinetic agent, on hunger, and the brain mechanism lying behind it.
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Primary Purpose: Basic Science
- Masking: Single (Participant)
- Study Primary Completion Date: September 2016
- Drug: Erythromycin
- Drug: Placebo
- physiological saline
Arms, Groups and Cohorts
- Placebo Comparator: Placebo
- intravenous infusion
- Experimental: Erythromycin
- intravenous infusion
Clinical Trial Outcome Measures
- Functional brain images
- Time Frame: 40 min after intervention
- The functional brain images will be taken via functional magnetic resonance imaging (fMRI), and be analysed via a software called SPM.
- hunger scores
- Time Frame: every 10 minutes since the scan starts
- The hunger scores will be taken every 10 minutes since the scan starts via a 10 cm visual analogue scale.
- gut hormones
- Time Frame: every 10 min since the scan starts
- Peripheral blood samples will be taken every 10 min since the scan starts until the endpoint of the study to measure gut hormones (motilin, ghrelin, CCK, PYY, GLP-1) by radioimmuno-assay.
Participating in This Clinical Trial
- Female only.
- Age > 18 and < 60.
- Body Mass Index (BMI) of 19-25 kg/m2 (no weight change of more than 5 kg in the past three months).
- Not known to have any chronic medical illness or illnesses affecting the gastrointestinal, cardiovascular, or nervous systems, chronic pain or psychiatric disorder.
- If female not known to be pregnant.
- Not known to have any past upper gastrointestinal surgery.
- Alcohol consumption > 7 drinks / week
- Major depression and chronic health conditions except controlled hypertension
Gender Eligibility: Female
Minimum Age: 18 Years
Maximum Age: 60 Years
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
- Lead Sponsor
- Universitaire Ziekenhuizen Leuven
- KU Leuven
- Provider of Information About this Clinical Study
- Overall Official(s)
- Jan Tack, Principal Investigator, University of Leuven
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